contraceptives Flashcards
MOA of both estogen and progestin
prevention of ovulation
How does estrogen change the endometrium?
stabilizes the lining → prevents irregular shedding and provides cycle control
How does progestin change the environment of the uterus?
increases viscocity of cervical mucus → inhibits sperm penetration
Three methods of Combined Hormonal Contraceptive
oral pil, transdermal patch, vaginal ring
what is the most common form of estrogen in COC, transdermal patch and the vaginal ring?
ethinyl estradiol
Pro of drospirenone and dienogest
bind primarily to progesterone receptors and have potential anti-adrenergic effects
Cons of earlier forms of progestin
bind to androgen receptors → side effects
Side effect seen if there is not enough estrogen in COC
early cycle spotting
side effects with too much estrogen
nausea and bloating, breast tenderness, headache, increased BP
Side effects with too little progestin
late cycle spotting
Side effcts of too much progestin
fatigue, breast tenderness, headache, mood changes
Side effects of too much androgen
acne, weight gain, hirsutism, increased LDL and decreased HDL
Which COC is FDA approved in treating acne?
4th generation progestin → drospirenone and dienogest
This COC has the same amount of estrogen and progestin in all the active tablets
monophasic
This COC has varying amounts of estrogen and progestin in the active tablets in attempt to minimize cumulative hormone doses and better mimic hormone levels throughout the menstrual cycle
multiphasic → biphasic, triphasic, quadriphasic
what are some things that COC products differ on?
type of estrogen, amount of estrogen, type of progestin, amount of progestin, androgenic activity, monophasic vs multiphasic, duration of cycle, number of active tablets, ethinyl estradiol in inactive tablets, iron or folate in inactive tablets
What do you consider when choosing an initial COC agent?
monophasic, product with < 35 mcg of EE and <0.5 mg norethindrone
What are the components of transdermal patch?
ethinyl estradiol and norelgestromin
How often does the patient have to reappy transdermal patch (ortho evra, xulane)?
every week and then a week off
Who is the transdermal patch not first line in?
women over 90kg
Black box warning for transdermal patch in comparision to COC?
increased risk of VTE → more exposure to estrogen than the pill
ADE for nuvargin (vaginal ring)
foreign body sensation, device expulsion, vaginal symptoms
what are the components of nuvaring?
ethinyl estradiol and etonogestrel
what are the components of annovera (other vaginal ring)?
ethinyl estradiol and segesterone
How does annovera differ from nuvaring?
provides contraception for a year → left in place for 21 days, removed for 1 week, SAME ring is reinserted
Who would benefit from annovera?
patient with little access to pharmacy