Contraception (Final) Flashcards
list some natural methods for non-hormonal contraception
- calendar (prevent pregnancy by knowing when you’re ovulating)
- basal body temperature
- cervical mucus method
- lactational amenorrhea
this is the temporary postnatal infertility that occurs when a woman is amenorrheic and fully breastfeeding (< 4hr daytime and 6 nighttime) and the baby is < 6 months
lactational amenorrhea
this is a barrier method; concern with allergies to latex or lanolin
condoms
this is a barrier method; may be inserted up to 8 hours before sex. more resistant than external condoms. hypoallergenic (made of nitrile polymer)
internal condom
this is a barrier method; may be isnerted up to 2 hours prior to sex and should leave in for at least 6 hours after sex. it is reusuable (for ab. 1-2 years). spermicide is REQUIRED for use. risk of TSS if left in for > 24 hours
diaphragm
this is a barrier method; can be inserted up to 1 hour prior to sex and should leave in for at least 6 hours after sex. risk of TSS and vaginal discharge/odour if left in for > 48 hours. it is reusable for up to 1 year
cervical cap
this is a barrier method; can be inserted anytime, should leave in for at least 6 hours after sex. contains spermicide (N9). single-use only. risk of vaginosis if left in for more than 30 hours
sponge
this contains N9 which immobilizes or kills sperm. should be inserted 15 mins before sex. risk of abbrations/irritation, which can increase risk of infections
spermicide
e.g. VCF contraceptive foam & film
this is less effective than N9. it helps seal the diphragm and lowers vaginal fluid pH which slows down sperm. may cause less vaginal irritation than N9. may be less effective at preventing pregnancy than a diaphragm + spermicide
lactic acid buffering gel
e.g. Contragel & Caya Gel
this is the most effective method of emergency contraceptive. it creates a cytotoxic environment that produces an inflammatory response that prevents fertilization
copper IUD
what is the onset of action for a copper IUD
effective immediately upon insertion
what are the contraindications for a copper IUD
- pregnancy
- unexplained vaginal bleeding
- current STI’s
- PID
- unknown distorted uterine cavity
- post-sepsis
- active intrauterine disease
what are the s/e of a copper IUD
mostly just inital pain and cramping or irregular bleeding due to inflammatory response. no hormones therefore not many other s/e :)
what happens to FSH levels when a follicle is developing (during menstruation and follicular/proliferative phase)
FSH decreases
what happens to LH levels when a follicle is developing (during menstruation and follicular/proliferative phase)
LH stays the same
what happens to estrogen levels when a follicle is developing (during menstruation and follicular/proliferative phase)
estrogen stays the same
what happens to progesterone levels when a follicle is developing (during menstruation and follicular/proliferative phase)
progesterone stays the same
what happens to FSH levels when the follicle has matured, at the time of ovulation
FSH slightly increases
what happens to LH levels when the follicle has matured, at the time of ovulation
LH levels spike
what happens to estrogen levels when the follicle has matured, at the time of ovulation
estrogen levels increase
what happens to progesterone levels when the follicle has matured, at the time of ovulation
progesterone levels stay the same
what happens to FSH levels during the luteum/secretory phase, when the corpus luteum is developing
FSH levels stay the same
what happens to LH levels during the luteum/secretory phase, when the corpus luteum is developing
LH levels stay the same
what happens to estrogen levels during the luteum/secretory phase, when the corpus luteum is developing
estrogen levels are decreased but then start to increase again
what happens to progesterone levels during the luteum/secretory phase, when the corpus luteum is developing
progesterone levels spike
what happens to FSH levels during regression of the corpus luteum as the next cycle starts to begin
FSH levels slightly increase
what happens to LH levels during regression of the corpus luteum as the next cycle starts to begin
LH levels stay the same
what happens to estrogen levels during regression of the corpus luteum as the next cycle starts to begin
estrogen levels increase
what happens to progesterone levels during regression of the corpus luteum as the next cycle starts to begin
progesterone levels decrease
this hormone in hormonal contraceptives prevents the release of FSH and keeps the ovaries inactive
estrogen
this hormone in hormonal contraceptives supresses the mid-cycle peaks of FSH and LH, increases the thickness and decreases the volume of cervical mucus which helps decrease sperm motility, it inhibits the development of the uterine lining and may inhibit ovulation in some women
progesterone
what generation are the following progestins used in COC:
Norgestimate & desogestrel
3rd gen
what generation are the following progestins used in COC:
norethindrone & ethynodiol
1st gen
what generation are the following progestins used in COC:
levonorgestrel & norgestrol
2nd gen
what generation are the following progestins used in COC:
drospirenone & dienogest
4th gen
this generation of progestins is associated with the most androgenic activity therefore more androgen s/e such as weight gain, acne, etc.
2nd gen - levonorgestrel and norgestrol
what estrogens are available in COCs
ethinyl estradiol and estetrol
In this type of combination birth control pill, each active pill contains the same amounts of estrogen and progestin.
monophasic
oral contraceptive pills have 3 different doses of progestin and estrogen that change approximately every 7 days.
triphasic
oral contraceptive pills that deliver the same amount of estrogen each day while progestin dose is increased halfway through cycle.
biphasic
what formulation (mono, bi or triphasic) should be used if using back to back hormone (no period)
monophasic
this COC contains a plant derived native estrogen - estetrol & drospirenone
Nextstellis
true or false: Nextstellis may be less effective in patients with a BMI > 30
true
true or false: pelvic exam, pap smear or STI screening are required before initiating COC
false
what are some risk factors that should be looked for when taking a patients medical hx prior to prescribing COC
- smoker
- obesity
- history of MI, stroke, angina or VTE
- uncontrolled HTN
- dyslipidemia
- uncontrolled DM
- migraine with aura
- hx of breast cancer
- hx of liver disease
- IBD
true or false: if a patient is less than 35 and smokes > 15 cigs/day, hormonal contraception should not be used
false - age < 35, the number of cigs does not matter
the advantages generally outweigh the risks
true or false: if a patient is >35 and smokes < 15 cigs/day, hormonal contraception should not be used
kinda true! - theoretical risks usually outweigh the advantages, take pt by pt
true or false: if a patient is > 35 and smokes > 35 cigs/day, hormonal contraception should not be used
true
unacceptable health risk
true or false: the risk of thromboembolism is greater in obese patients
true
which hormonal contraceptive option has weight gain as a possible side effect
depo-provera
true or false: ethinyl estradiol is an inhibitor of CYP 3A4
false - inducer, therefore lowers levels of CYP 3A4 substrate
true or false: ethinyl estradiol is a CYP 3A4 substrate, therefore inducers such as phenytoin will increase the metabolsim of ethinyl estradiol furthermore decreasing its effectiveness
true
true or falase: if a patient is on a strong CYP 3A4 inducer, then the preferref treatment is Depo-Provera q 12-13 weeks or LNG IUD
false - Depo Provera q 10 weeks or LNG IUD
q 12-13 weeks is normal regimen
when gathering a patients menstruation history, what are some questions you should ask?
- has the patients reached menarche
- when was their last period
- has the patient has unprotected sex since their last period
- does the patient have undiagnosed vaginal bleeding
what are the criteria that can rule out pregnancy
no signs or symptoms of pregnancy AND one of the following:
- exclusively breastfeeding, amenorrheic and < 6 months postpartum
- no intercoirse since last menses
- correctly using reliable contracpetion
- < 7 days after menses
- < 7 days after abortion or miscarriage
- < 4 weeks postpartum
what are the two options for conventional dosing for COC
1 tablet daily x 21/7, then 7 days of no pills
1 tablet daily x 28/7 (last 7 tablets are non-hormonal)
*can take continuously but should avoid multiphasic
what are some advantages of extended/continuous use COC
- decrease dysmenorrhea
- may improve other sxs associated with menstrual cycle
- convenient (delays or eliminates menstruation)
- good adherence
what are some disadvantages of extended/continuous use COC
- possible delay in the recognition of pregnancy
- unscheduled bleeding and spotting
if a patient misses their COC pill that they were supposed to take <24 hours ago, what should they do?
take 1 active pill ASAP and continue pack as usual
if a patient misses their COC pill that they were supposed to take >24 hours ago, what should they do?
see product monograph
true or false: progestin only pills must be taken within a 3 hour window daily for 28 days with NO hormones free interval
true
true or false: when starting a POP, 2 days of backup is required if you start on day one of menses
false - no back up required