Contact Dermatitis Exam 3 Flashcards
Characterized by inflammation, redness, burning, itching, and pustule formation on skin
Contact Dermatitis
2 Types of Contact Dermatitis
Irritant Contact Dermatitis (ICD)
Allergic Contact Dermatitis (ACD)
Inflammatory reaction due to exposure to irritant substances
Irritant Contact Dermatitis (ICD)
Immunologic reaction caused by exposure to an antigen
Allergic Contact Dermatitis (ACD)
Mechanisms of ICD`
Disruption of skin barrier
Changes in cells of epidermis
Release of pro-inflammatory cytokines
Most commonly affected areas are __________ (often due to exposure)
Hands and face
______ % of cases have hand involvement
80%
Existing skin conditions ____________ can result in worse cases of ICD
Atopic Dermatitis
Can effect individuals of any age
Infants and elderly more at risk due to ________
thinner epidermal layers
________ can play a role in type of exposure
occupation
Substances associated with ICD
Strong acids (hydrochloric, sulfuric) Strong bases (sodium, potassium) Detergents, soaps Fiberglass Oils Urine/feces Wood dust
Clinical Presentation of ICD
Inflammation and swelling Itching and burning Rash Hyper/hypo-pigmentation Scaling of skin, dryness
Goals of Therapy ICD
Remove the offending agent
Relieve inflammation and irritation
Educate patient on prevention and treatment
Non-Pharmacologic Therapy for ICD
Flush area with tepid water and mild soap
Non-Pharmacologic Prevention for ICD
Wear protective clothing
Use of emollients and barrier creams
Pharmacologic Treatment Options
Emollients
Colloidal Oatmeal Baths
Topical Corticosteroids
Immunologic reaction caused by allergen-specific T lymphocytes
Allergic Contact Dermatitis (ACD)
T cells migrate to site of contact and release inflammatory mediators
Allergic Contact Dermatitis (ACD)
ACD requires ________
sensitization
Induction Phase of ACD
Immune system sensitized by first exposure to antigen
Elicitation Phase of ACD
Cell-mediated, type IV delayed hypersensitivity reaction
Rash and symptoms typically appear within 24-48 hours, can take days
Epidemiology of ACD is frequency based on exposure such as
Occupation
Hobbies/Habits
Regional allergens
Epidemiology of ACD affects all ages, races and sexes and usually start to see around ______ years old
2-3 years old
Clinical Presentation of ACD
Localized to site of skin contact with allergen
Symptoms may not appear for hours to days
delayed hypersensitivity with ACD
Symptoms of ACD
Severe itching Rash (skin red, swollen, and hot) Excessively dry skin Fluid-filled blisters Oozing blister that leave crust or scales
Substances Associated with ACD
Poison Ivy, Oak, Sumac Metal (Nickel) Lanolin Latex Neomycin Rubber Fragrances Adhesives
Among most common causes of ACD
Poison Ivy, Oak, Sumac
Dermatitis reaction is caused by exposure to
urushiol
urushiol can only be released through damage to the
plant
For Poison Ivy, Oak, & Sumac All members of the Toxicodendron genus. Exist mostly as
shrubs and vines
Important to wash hands after potential exposure to poison ivy, oak & sumac to prevent transfer to other body sites such as
eyes
lips
genitalia
Urushiol Induced Dermatitis has a highly variable presentation based
on patient sensitivity and extent of exposure
Urushiol can form
papules, plaques, or fluid-filled vesicles
______ cannot cause further transfer of dermatitis
Vesicular fluid
Complications of ACD include
secondary infections
For ACD scratching can further damage the dermal layer, creating ________-
open lesions
Lesions can then become infected with microbes from the skin like
Staphylococcus aureus
Group A Streptococcus
Escherichia coli
Goals of Therapy for ACD
Remove offending agent
Treat inflammation
Relieve itching that may lead to open lesions
Relieve accumulation of debris from oozing and crusting
Exclusions for Self-Treatment for ACD
< 2 years old
> 20% Body Surface Area (BSA)
Dermatitis present > 2 weeks
Presence of numerous bullae
Discomfort in genitalia from itching, redness, swelling, or irritation
involvement of or itching mucous membranes
failure of self treatment after 7 days
low tolerance for pain, itching, or discomfort
What formula is used for BSA
Mosteller Formula
Non-Pharmacologic Treatment for ACD
Cold or tepid shower to help reduce itching
Non-Pharmacologic Prevention for ACD
Avoid offending agent
Protective clothing
Pharmacologic Treatment for ACD
Topical Corticosteroid (Hydrocortisone 1% cream) Astringent compress Calamine products Colloidal oatmeal products Oral antihistamines
Avoid using what for Pharmacologic Treatment for ACD
topical antihistamines
topical anesthetics
topical antibiotics
Prevention of Poison Ivy, Oak, Sumac
Learn to identify Toxicodendron plants.
Eradicate them from your residence.
Use protective clothing and wash separately immediately after exposure
Use barrier products
FDA approved protection against poison ivy/oak/sumac
Active Ingredient: Bentoquatum
IvyBlock Lotion
Ivy Black Lotion application
Apply before 15 minutes before exposure and reapply every 4 hours.
Contact Dermatitis in Pediatrics
similar to adults – pay attention to package
Contact Dermatitis in Pregnancy
Short term use of topical agents generally considered safe
Contact Dermatitis in Geriatrics
Avoid first generation antihistamines
Follow up for ICD & ACD in
After 5 to 7 days of treatment
Complete resolution for ICD & ACD may take up to
3 weeks
When do contact provider for ICD & ACD?
Rash increase in size Symptoms worse Doesn't begin to improve within 7 days Spreads to or involves other genitals Covers extensive areas of the face or causes swelling of the eyelids
Itching begins when for ICD?
later
Itching begins when for ACD?
early
Stinging/Burning begins when for ICD?
early
Stinging/Burning begins when for ACD?
late or not at all
Does Vesicles, Bullae, Papules present in ICD?
rarely
Does Vesicles, Bullae, Papules present in ACD?
yes
What is the time to rash after exposure for ICD?
minutes to hours
What is the time to rash after exposure for ACD?
hours to days
Appearance of symptoms in relation to exposure for ICD
initial or repetitive exposure
Appearance of symptoms in relation to exposure for ACD
delayed
Causative Substances for ICD
Water, urine, flour, detergent, hand sanitizer, soap, alkalis, acids, solvents, salts, oxidizer, surfactants
Causative Substances for ACD
Toxicodendron plants, fragrances, nickel, latex, benzocaine, neomycin, leather
Substance concentration at exposure important for ICD?
Yes, Important
Substance concentration at exposure important for ACD?
Less important
Mechanism of reaction of ICD
Direct tissue damage
Mechanism of reaction of ACD
Immunologic reaction
Common Location of ICD
Hand, wrists, forearms, diaper area
Common Location of ACD
Anywhere that comes in contact with antigen
Presentation of ICD
No clear margins
Presentation of ACD
Clear margins based on offending agents
Who can be affected with ICD?
anyone
Who can be affected with ACD?
patients with allergy