Consolidation

Question 1

What kind of carcinogen most commonly causes GI cancer?

Answer 1

Nitrosamines

Question 2

What is Li-Frameni syndrome?

Answer 2

Mutation of p53 transcription factor tumour suppressor gene

Therefore cell cycle cannot arrest properly in times of stress to repair

Question 3

What genetic condition is characterised by numerous fibrous tumours on nerve sheaths?

Answer 3

Neurofibromatosis

Question 4

Which chromosomes are the following found on?

1) p53
2) NF1
3) NF2
4) BCR
5) ABL

Answer 4

1) 17
2) 17
3) 22
4) 22
5) 9

Question 5

What produces gastric acid, intrinsic factor and pepsinogen?

Answer 5

GA and IF: Parietal cells

Pepsinogen: Chief cells

Question 6

NOD 2 gene is associated with?

Answer 6

Crohn’s

Question 7

What condition is characterised by Gastrin-secreting adenomas which cause increased acid secretion and peptic ulcers?

Answer 7

Zollinger Ellison syndrome

Question 8

List the hepatits viruses, their spread and genetic type, does each have a chronic or acute course?

Answer 8

A - enteral - acute - RNA
B - fluids - chronic - DNA
C - fluids - chronic - RNA
D - fluids - chronic - RNA
E - enteral - acute - RNA

Question 9

Which hepatitis has a high mortality rate among pregnant women?

Answer 9

E

Question 10

What is Virchows triad?

Answer 10

Three things which promote thrombosis

Hypercoagulability
Turbulent flow
Endothelial damage

Question 11

99% of stenoses are caused by?

Answer 11

Rheumatic carditis

Question 12

What disease is characterised by vasospasm in response to emotional stress and cold?

Answer 12

Reynaud’s disease

Question 13

What is pericarditis after an MI referred to as?

Answer 13

Dressler syndrome