Consequences of alcohol Flashcards

1
Q

How much alcohol should men and women drink in a week?

A

14 unis

= spread evenly over 3 days or more

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2
Q

what are haematological effects of alcohol?

A

Chronic

  • anaemia
  • bone marrow suppression
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3
Q

what are CNS effects of alcohol?

A

Acute
= violence
= accidents

Chronic
= cerebellar degeneration
= dementia
= neuropathy

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4
Q

what are GI effects of alcohol?

A

Acute

  • oeosphagitis
  • acute pancreatitis
  • gastritis/ulceration

Chronic

  • stomach
  • liver
  • pancreas
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5
Q

what are resp effects of alcohol?

A

Acute

  • aspiration
  • overdose
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6
Q

what are CV effects of alcohol?

A

Chronic

  • hypertension
  • cardiomyopaty
  • MI
  • stroke
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7
Q

what are musculoskeletal effects of alcohol?

A

Chronic

  • proximal myopathy
  • osteoporosis
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8
Q

what are 3 other effects of alcohol?

A
  • endocrine
  • dermatologic
  • reproductive
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9
Q

what is foetal alcohol syndrome?

A

= when children are exposure to alcohol in utero

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10
Q

how many drinks when pregnant can cause damage to a foetus?

A

= 7-14drinks a week (particular > 5 occasions)

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11
Q

what are consequences of foetal alcohol syndrome?

A
  • growth deficiency
  • mental retardation/intellectual impairment
  • attentional leraning disability
  • behavioural problems
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12
Q

what are signs of chronic liver disease?

A
  • stigmata: spiders, fetor, encephalopathy
  • synthetic dysfunction
  • prolonged prothrombin time, hypoalbuminaemia
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13
Q

what are signs of portal hypertension?

A
  • caput medusa
  • hypersplenism
  • thrombocytopenia (pancytopenia)
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14
Q

what are essential features of alcoholic hepatitis?

A
  • recent excess alcohol
  • bilirubin > 80
  • exclusion of other liver disease
  • AST < 500 (AST:ALTT ratio > 1.5)
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15
Q

what are symptoms of alcoholic hepatitis?

A
  • hepatomegaly
  • fever
  • leucocytosis
  • hepatic bruit
    = in appropriate context
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16
Q

what is used to evaluate the severity and prognosis of alcoholic hepatitis?

A

= maddrey’s discriminant function

= 4.6 x (PT patient - PT cont) + [serum bilirubin / 17.1]
= score of > 32 correlates 45% mortality at 28day

17
Q

describe what can be used to treat alcoholic hepatitis?

A
  • pentoxifylline (in severe AH, no benefits)

- prednisolone (beneficial short term)