connective tissues disorders

Question 1

what populations have the highest prevelens of systematic lupus Erythematosus

Answer 1

1.Afro-Caribbean
2. Asian
3. caucasian

Question 2

SLE is more prevalent in males or females

Answer 2

Females
-90% affected are female

Question 3

what is the genetic association of lupus

Answer 3

HLA: DR2, DR3

Question 4

what is the signature rash of acute SLE

Answer 4

butterfly/malar rash and a discoid rash

malar rash has sparing of nasolabial folds

Question 5

What are some SLE criteria to diagnose from

Answer 5

4 or more of

• malar rash
• discoid rash
• photosensitivity
• oral ulcers
• arthitis
• serositis
• renal disorders
• haematological disorders
• neurological disorders
• immunologic disorder
• Ana test - Anti nuclear antibodies

Question 6

what are the inherited connective tissues disorders

Answer 6

marfans
eds
osteogenesis imperfecta

Question 7

what are some signs of marfans

Answer 7

pectus excavatun
mitral valcer prolapse
arachnodactlyly

Question 8

what are some signs of EDS

Answer 8

stretchy skin
hypermobille joints

Question 9

list some autoimmune Connective tissie disorders

Answer 9

• SLE
• Primary Sjögren’s Syndrome
• Dermatomyositis/ Polymyositis
• Systematic sclerosis

Question 10

what is the difference between primary and secondary raynauds

Answer 10

primary - no known cause
Secondary

Question 11

what are the clinical signs of dermatomuositis

Answer 11

heliotrioe rash
gottron papules

Question 12

what are investigations for dermatomyositis

Answer 12

• Muscle menxymes -ck
• Antibody screen
• EMG
• biopsies
• malignancy screen - PET