connective tissues disease Flashcards
how are multisystemic vasculitic inflammatory diseases managed?
- analgesic NSAIDS
- Immune modulating treatment - methotrexate/azathioprine
- Biological medication - cytokine inhibitors and lymphocyte depleting drugs
- Systemic steroids - prednisolone
Systemic Lypus Erythematosis causes what?
Tissue changes without blood autoantibodies called ‘Discoid Lupus’
Seen in the skin and the mouth – looks similar to lichen planus
Systemic Lypus Erythematosis affects which systems of the body?
joints, skin, kidney, muscles, blood
CVS, RS & CNS
Systemic Lypus Erythematosis enhances the risk of what happening?
cardiovascular complications
Systemic Lupus Erythematosis is more common in which group of people?
Twins 20-50% concordance
females of child bearing age
Systemic Lupus Erythematosis can manifest in what way on the face?
Butterfly zygomatic rash due to photosensitivity
What are the dental implications of Systemic Lupus Erythematosis?
- Chronic Anaemia - oral ulceration/GA risk
- Bleeding tendency/thrombocytopenia
- Renal disease - impaired drug metabolism
- Steroid & immunosuppressive therapy - possible increased malignancy risk
- lechenoid oral reactions
- Oral pigmentation - hydroxychloroquine use
Sjogren’s Syndrome is mainly associated with?
- circulating autoantibodies
- dry eyes and dry mouth
- Primary sjogrens - not associated with any other disease
- secondary sjogrens - associated with another connective tissue disease such as rheumatoid arthritis
How is Sjogren’s Syndrome tested for?
- No one test can diagnose it, clinical judgement based off:
- Autoantibody findings
- Imaging findings
- histopathology findings
what are the dental implications for Sjogren’s Syndrome?
- oral infection
- Caries
- Function loss
- Denture retention (no saliva)
- Sialosis (swelling of salivary glands)
- salivary lymphoma
What is Systemic Sclerosis?
excessive collagen deposition
connective tissue fibrosis
loss of elastic tissue
how does Systemic Sclerosis present?
- raynauds phenomenon
- nailfold capillaroscopy
- telangiectasia
What are the Dental Aspects of systemic sclerosis?
- poor mouth opening
- limited tongue movement
- can be compounded by sjogrens
- pain on swallowing or difficulty to swallow
- cardiac and renal vasculitic disease
- widening of periodontal ligament space
Giant cell arteritis mainly affects which blood vessel?
*Temporal Artery
Giant cell arteritis may present as?
*headache/facial pain
