Connective Tissue Flashcards
Principal cell of connective tissue
Fibroblast
Produces matrix
Fibroblast
Abundant along the course of blood vessels
Adipose cells
Pluripotent connective tissue cell
Mesenchymal cell
Irregular surface cytoplasm
Macrophage
Deployed along collagen fibers
Fibroblast
Rarely divide in normal connective tissue
Fibroblast
Enumerate the fixed connective tissue cell
- Fibroblast
- Macrophage
- Adipose cells
- Mesenchymal cells
Enumerate the free cells
- Lymphocytes
- Plasma cells
- Eosinophils
- Mast cells
- Basophils
- Neutrophils
Cells that produce antibodies
- B lymphocytes
2. Plasma cells
Oval with eccentric nucleus
Plasma cells
Fusiform cells
Fibroblast
Mesenchymal cells
Responsible for cell mediated immunity
T-lymphocytes
Responsible for humoral immune system
B lymphocytes
Responsible for humoral immune system
B lymphocytes
Programmed to kill virus infected cells and tumor cells
Natural killer cells *similar to macrophage
Derived from B lymphocytes
Plasma cells
Round with bilobed nucleus and pink coarse cytoplasmic granules
Eosinophils
Eccentric bean shaped nucleus
Monocytes
Large ovoid with spherical nucleus
Mast cells
Basophilic granules contain histamine, heparin and eosinophilic chemotactic factor
Mast cells
Where is mast cell located?
Mucous membrane and skin
Abundance of Fc receptors for IgE antibodies in cell membrane
Basophils
What cell that causes hypersensitivity reaction allergy or anaphylaxis when granules are released?
Mast cells
Invades the CT when there is inflammation and infection
Neutrophils
Present only in abnormal connective tissue
Neutrophils
Multilobed nucleus with granules
Neutrophils
3 parts of ECM
Ground substance
Basement membrane
Fibers
Types of ground substance
Glycosaminoglycans
Structural glycoproteins
Types of GAGs
Hyaluronic acid Dermatan sulfate Chondroitin sulfate Keratan sulfate Heparan sulfate
GAG + core protein
Proteoglycans
Involved in the interaction of cells with ECM (adhesion)
Structural Glycoproteins
Examples of structural glycoproteins
Fibronectin
Laminin
Thrombospondin
Part of clotting cascade and adhesion of platelets
Thrombospondin
Deployed along collagen fibers
Fibroblast
Contains desmosine and isodesmosine
Elastic fibers (elastin)
Give rise to differentiated cells that function in repair and formation of new tissue
Mesenchymal cells
Associated with allergic reaction, parasitic infection and chronic inflammation
Eosinophils
Derived from monocyte
Macrophage
Precursor of macrophage
Monocyte
Function as APC
Monocyte
Differentiate Mast cell vs Basophils
non-lobe nucleus (mast cell) - bilobed nucleus (basophil)
Components of Basement membrane
Type IV collagen
GAGs (heparan sulfate)
Structural glycoproteins
Makes up 30% of dry BW
Collagen
Composition of Collagen
Glycine 33.5%
Proline 12%
Hydroxyproline 10%
Give the Collagen Types and corresponding locations
Type 1: cartilage bone
Type 2: hyaline cartilage
Type 3: located in surroundings of organs (reticular fibers)
Type 4: basement mebrane
Example of Type III collagen
Reticular fibers
composition of type iii collagen
made up of fibrils
abundant in smooth muscle covering spleen and liver
reticular fibers
provide supporting framework
reticular fibers
35 nm in diameters/ 0.5-2 um in diameter
reticular fibers
0.2 - 1 um / 10 nm in diameters
Elastic fibers
what structures compose elastic fibers?
Central core: elastin (desmosine and isodesmosine)
Surrounding: fibrillin - glycoprotein
allow tissue to respond to stretch and distention
elastic fibers
what is elastic fiber elastic?
due to unusual polypeptide backbone that causes random coiling
cause of marfan syndrome
abberance in elastic fibers
similarities between elastin and collagen
same synthesis pathway
ennumerate the fibers
collagen
reticular fibers
elastic fibers
ennumerate connective tissue proper
Loose connective tissue
Dense irregular connective tissue
dense connective tissue
examples of dense regular connective tissue
tendons
ligaments
impt role in oxygen diffusion and nutrients from vessel
Loose connective tissue
describe LCT
abundant ground substance
thin and sparse collagen
located beneath epithelium