connective tissue Flashcards
where does CT arise from
Mesoderm
name the 3 types of CT fibres
collagen, reticular, elastin
Where is collagen made and what are its uses
Made from fibroblasts and uses are: cushioning, strength, found info cartilage, tendons, ligaments
Structure of collagen
3 chains of alpha helices, rich in glycine and proline
Reticular: what is it made from and its uses
Made from fibroblasts, are short fibres, in lymph nodes and bone marrow. They produce scaffolding that cells can grow through
Elastic fibres: where is it found
bundles of elastin found in ECM and smooth muscle cells in arteries
Structure of elastin fibres
Held together by cross bridges, stretch and recoil
What are fibroblasts and their features
Fibroblasts are active. Round, euchromatic nucleus, lightly stained, abundant in cytoplasm, lots of RER e.g. found in umbilicus
What are Fibrocytes
Inactive, flat, heterochromatic nucleus, scant cytoplasm, little RER e.g. found in tendons
what are adipocytes and their features
fat cells
contain lots of SER and pinocytis vesicles for endocytosis
have sleeve of collagen 3 as a coat
Are negatively charged and retain Na + and other ions. Have pockets that can store water. Can from gels
Difference between white and brown fat cells?
White: Uniocular, one large fat droplet, nucleus to the side
Brown: multiocular, many smaller droplets
Use of thyroid hormones?
Liberty fat from cells to be metabolised
What are GAGs
Glycosaminoglycans (GAGs) are long unbranched polysaccharides consisting of a repeating disaccharide unit. Examples: Hyaluronic acid, Chondroitin sulphate, Heparin sulphate, keratan sulphate