Connective Tissue Flashcards
What forms CT
Fibroblasts synethesise and maintain extracellular material
What are myofibroblasts
Cotnractile fibroblasts that shrink scar tissue in wound healing
What cells produce and maintain cartilage
Chondroblasts and chondrocytes
What is the extracellular material?
Hydrated polysaccharide gel containing glycoprotein mesh
fibrous adhesion proteins - laminin, fibronectin, tenascin
Fibres - collagen and elastic
Structural proteoglycans
What are laminins
Family of glycoproteins that are an important component of the basal lamina
Large heterotrimeric molecules formed form alpha, beta and gamma chain
What are function of laminins?
Ancho cell surfaces to basement membrane
form networks with type 4 collagen via percalan and with cell membranes via integrin receptors
What is fibronectin
Adhesive extracellular matrix glycoprotein
Binds to membrane spanning receptor proteins called integrins and ECM components such as collagen fibrin and heparin sulphate proteoglycans
roels in cell adhesion, growth, migration and differentiation
What are proteoglycans
Protein and consist of core protein that is linked via a serine to one or more GAGs
GAG = repeating disaccharide units forming unbranched polysaccharide
What are the main type of GAG?
Hyaluronic acid
Chrndroiin sulphate
Dermatan sulphate
Heparin sulphate
Heparin
Keratin seulphate
What do GAGs do in relatino to water
Hydrophilic
Net negative charge that attracts Na+ that draws water into matrix giving turgor pressure
What is collagen?
Fibrou protein resistant to stretchin
Rich in proline and glycine
Left handed helix
2 molecules twist to form microfibrils
Bundle together to form fibrils
Bundle together to form fibres
What is type 4 collagen
Non-fibrillar, sheet like network found in basal lamina
