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Structure and Function: Block 1 > Connective Tissue > Flashcards

Connective Tissue Flashcards

1
Q

What is connective tissue proper?

A

1) Loose connective tissue
2) Dense connective tissue
- Either arranged irregularly or regularly in a parallel manner

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2
Q

Where are all connective tissues derived from?

A

Embryonic mesoderm which develops to embryonic mesenchyme.

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3
Q

What are the stem cells for connective tissue?

A

Mesenchyme

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4
Q

What do mesenchymal cells secrete?

A

Hylauronic acid-rich ground substances: function as fibroblasts

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5
Q

What resembles primitive mesenchyme?

A

Mucoid (mucous) connective tissue

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6
Q

Where is mucoid tissue found?

A

1) Umbilical Cord
2) Fetal organs
3) Pulp cavities of teeth

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7
Q

What is the most abundant cell in connective tissue?

A

Fibroblasts

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8
Q

What cell secretes the majority of the ECM?

A

Fibroblasts

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9
Q

What do fibroblasts secrete?

A

1) Collagen

2) Elastin

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10
Q

What are macrophages derived from?

A

Monocytes

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11
Q

What is the name for macrophages that reside in tissue?

A

Histiocyte

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12
Q

What are the functions of histiocytes?

A

1) Clear debris
2) Present antigens
3) Secrete growth factors

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13
Q

What are histiocytes in the liver?

A

Kupffer cells

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14
Q

What are histiocytes in the CNS?

A

Microglia

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15
Q

What are histiocytes in the bone?

A

Osteoclasts

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16
Q

What are histiocytes in the lung?

A

Alveolar macrophages

17
Q

What are histiocytes in the skin?

A

Langerhans cells

18
Q

What cell is derived from basophils?

A

Mast cells

19
Q

What are mast cells filled with?

A

Basophilic granules that are metachromic and contain highly sulfated GAG (purple/red)

20
Q

What are plasma cells derived from?

A

B lymphocytes

21
Q

Why do plasma cells have abundant RER?

A

They are part of the immune system and produce A LOT of antibodies, which are proteins.

22
Q

How are plasma cells identified at the LM level?

A

Clock-face appearance

23
Q

What are the fibrillar collages that are mostly produced by fibroblasts?

A

1) Type I
2) Type II
3) Type XI

24
Q

What is the location/function of collagen type I fibers?

A

Location: Skin, bone, tendon
Function: Resistance to tension

25
Q

What is the location/function of collagen type II and XI?

A

Location: Cartilage
Function: Resistance to Pressure

26
Q

What is the function/location of type III collagen?

A

Location: Reticular fibers of skin and vessels
Function: Structural support in expansion; comprises reticular lamina

27
Q

What is the function/location of type IV collagen?

A

Location: Basal lamina
Function: Supports epithelial

28
Q

What is the fxn/loc. of type VII collagen?

A

Location: Basement membrane
Function: Anchors basal lamina to reticular lamina

29
Q

What is the structure of procollagen?

A

Triple helix

30
Q

What kind of bonds stabilize procollagen?

A

Disulfide bonds

Structure and Function: Block 1 (6 decks)

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