Conj disease Flashcards
What is a conjunctival cyst?
= inclusion/retention cyst
- fluid filled sac
potential symptoms of conjunctival cyst?
irritation
What are concretions?
mucous secretions + epithelial cells + calcium
another name for conj concretions?
ocular lithiasis
When do you treat conj concretions?
if bothersome or stain, can remove
What is a conj nevus?
proliferation of melanocytes
when does a conj nevus develop?
puberty/ early adulthood
by 20s
can increase in size during puberty
what are characteristics for a conj nevus?
What is diagnostic for conj nevus?
unilateral, usually only one
mobile
30% non-pigmented
INCLUSION CYST inside
what is the most common location for a conj cyst?
juxtalimbal > plica/caruncle
what are melanosomes?
organelle in melanocytes
- contains melanin
what type of cancer can conj nevus cause?
melanoma
What is primary acquired melanosis?
unilateral (usually flat) acquired pigment with indistinct margins
What is PAM a precursor to?
Malignant melanoma - 30% of patients (biopsy)
NOTE: usually benign
what are signs that PAM is melanoma?
nodular
increased vascularity
increased growth
*** does not have to be pigmented
Who gets conj melanomas?
50 year old white people
- hx of PAM (75%)
- nevus (30%)
What is the most important prognostic indicator for malignancy in a conj melanoma?
thickness
What is the most common site for metastasis for a conj melanoma?
liver
What is the most common conjunctival neoplasia in the US?
CIN - conjunctival intraepithelial Neoplasia
what are other names for CIN?
Bowen’s disease
conjunctival squamous dysplasia
What is CIN?
unilateral, pre-malignant condition that can progress to squamous cell carcinoma
what is the risk of CIN progressing to a cancerous lesion?
low - because the basement membrane is usually intact.
what are risk factors for developing cancer from CIN?
UV-B light
smoking
exposure to petroleum derivatives
fair skin
xanthoderma pigmentosa
HIV
HPV
How do you distinguish benign vs malignant/pre-malignant lesions?
toluidine blue 0.05%
What is Conjunctival squamous cell carcinoma? who gets it? located? cause? diagnositc?
rare, slow - growing malignant tumor.
white old males
limbus, can involve adjacent cornea
seen at limbus
CIN, UV radiation, HPV
usually has a feeder vessel
what is pyogenic granuloma
pedunculate, benign, red, vascular lesion of the conj
what causes pyogenic granuloma
trauma
sx
chalazion
CHRONIC IRRITATION
what is Conjunctival ganuloma?
inflamed area in the con storm secondary to a foreign body, surgery trauma, infection or systemic condition (sarcoid)