Confusion in the Elderly Flashcards
Mental health and aging
- Cognitive loss
- Psycological diseases of old age
- Psychosocial issues of the elderly
- Medical legal issues (MDM capacity, dpoa – designated power of attourney)
Confusion: the common denominator
- Wrongly believed to be due to aging
- The medical differential diagnosis
- The in-the-trenches differential diagnosis: the three D’s
- You should, for any sx, be able to produce a differential for any give sx
The three Ds
- Dementia
- Delirium
- Depression
- If you have altered level of consciousness, these should be your first differentials
Confusion in the elderly
- Confusion is variable – the question is how does the confusion present
- Constant versus intermittent – this tells you a lot!
- If you get a UTI, the confusion is intermittent (you won’t be confused for the rest of your life)
- Acute versus chronic – Parkinson’s doesn’t hit you over night –> if all of a sudden you have all the sxs, that’s NOT Parkinson’s, its probably a side effect from an antipsychotic
- Differs from symptoms of mental illness in younger people – not everyone has the same adverse drug effects
- BASELINE –> very important in discussion of cognition
- If their baseline is nonverbal and you assess them and they can’t talk, this is NORMAL FOR THEM
- No new schizophrenia in old age (but lots of antipsychotics)
- Antipsychotics are used to treat agitation and aggression in the ER and they are also the preferred tx for schizophrenia
- YOU CAN’T BE A CRACK HEAD AND BE CONSIDERED SCHIZOPHRENIC –> you can’t be on any influence when diagnosed
- Constant versus intermittent – this tells you a lot!
Dementia
- Hallmark: loss of recent memory
- Insidious onset
- Impaired judgement
- Behavioral issues
- Sleep disturbance
- Aggression
- Early versus late issues
- Early dementia is not the same as late dementia
- Demented people lose their ability to perform ADLs
Diseases that cause dimentia
- Alzheimer’s disease 70%
- Multi-infarct (stroke)
- Lewy body (amyloid plaques)
- HIV – late stage HIV people
Diseases associated with dimentia
- Parkinson’s disease
- B12 deficiency
- Thyroid disease
- Liver disease
- Encephalopathy – certain disease processes cause encephalopathy (i.e. Hep C, kidney issues)
- These are not dementia in and of themselves but they create dementia à you can use these to prevent dementia
Alzheimers dz probable criteria
- Dementia
- Clinical exam eg r/o others
- Mental status evaluation
- Deficits in >2 cognitive areas
- Progressive decline
- Normal level of consciousness (encephalopathy is NOT a normal level of consciousness)
- Onset between 40-90 yrs
- No other cause
- Supportive factors
- +family hx
- Cerebral atrophy
- Normal EEG
- Normal lumbar puncture
- Clinical criteria + histopathology
Alzheimers dz definite criteria
- Risks:
- Nonmod: age, fam hx, APOE-4 gene, down syndrome
- Mod: head trauma, HTN, DM, smoking, depression
- Age:
- Prevalence of AD doubles every 5yrs > 60
- 85yo has 50% risk of AD
- 2x parents with AD = 54% risk by 80yo
- 1st degree relative with AD: risk is double that of general population
Stages of Alzheimers
- Early
- Gradual memory loss
- Preserved level of consciousness à they’re aware of where they are, they know whats going on
- Impaired ADLs
- Subtle language errors
- Impaired spatial perception à they are at an increased fall risk
- Late
- Aphasia: no speaking
- Apraxia: no purposeful actions – think walking à people can walk, but they don’t know where they’re walking to
- Agnosia: no recognizing/interpreting – they have a hard time understanding language, they cant interpret things in the way that you mean them
- Inattention
- Left-right confusion – you say left and they reach to their right
Dementia ddx
- Agnosia, aphasia an apraxia shared with other dementias
- AD specific: word finding issues, apathy/indifference, delusion, disorientation
- Delusion = woman who had uterine cancer and refuses blood transfusion because she doesn’t want other people’s blood and she is going to leave and drive across the country
Lewy body dementia
-
Mild Parkinsonism sxs (shaking, tremor gait)
- Parkinsonism sxs: pill rolling tremor on one side or both sides, shaking, masked facies, shaking
- Unexplained falls
- Visual hallucinations – talking to someone under the bed
- Fluctuating cognition – sometimes theyre with you and sometimes they are not
- Extreme sensitivity to antipsychotic medications
- Confirmation dx: +amyloid plaques on PET scan à DIAGNOSTIC TEST!!
- A diagnosis of Lewy body dementia requires a progressive decline in your ability to think, as well as two of the following:
- Fluctuating alertness and thinking (cognitive) function
- Repeated visual hallucinations
- Parkinsonian symptoms
Frontotemporal dementia
- Onset before 60
- Language disarray
- Profound personality changes
- Behavioral issues – have a very odd affect
- Impulsive – have no impulse control
- Hypersexual – sexually motivated
Type of Frontotemporal dementias
- Progressive supranuclear palsy: PSP a degenerative disease of specific regions of brain
- Primary progressive aphasia: language slowly impaired, not other mental functions
- Semantic dementia: loss of word meaning
- ALS with dementia: Amytrophic lateral sclerosis (neurogenerative dz)
Vascular dementia - multiinfarct dementia
- Stepwise deterioration 2/2 (secondary to) ischemic events
- Normal level of consciousness
- Functional loss may correlate with cerebrovascular events (CT/MRI)
- Types: cortical, subcortical, white matter lesions, mixed or specific – all depend on where the stroke is!
- They have a stepwise approach – every time they have a stroke, their symptomology changes a bit
- YOU DON’T WANT TO MISS VASCULAR EVENTS!!! It’s a red flag! You need to ALWAYS consider a vascular even
- You can get a CAT scan or MRI to confirm
- You don’t get a CAT scan on everyone you think has dementia
- ACUTE ONSET à TELLS YOU TO GET A SCAN!!!
Confusion in the elderly: dementia
- Diagnosis
- “rule-out” treatable causes (e.g. other D’s)
- The role of imaging
- Mental status
- Screening
- MMSE
- MOCA
- Full assessment
- Screening
- Treatment and management
- Education of patient and family
- Rx
- Develop strategy for caregiver respite
- Long-term care planning
Mini mental state exam
- Strengths
- Standardized, widely used
- Reproducible validity
- Quickly administered
- Useful scoring
- Limitations
- Does not test executive function
- No correlative with capacity
- Screening tool
- Education dependent
- Not culturally valid
Montreal cognitive assessment
- Visuospatial/Executive
- Naming
- Memory
- Attention
- Language
- Abstraction
- Delayed recall
- Orientation
Dementia management
- Facilitate environmental success
- Stimulate cognitive function with challenges
- Promote feelings of pleasure
- Don’t force it
Confusion in the elderly: delirium
- Acute onset
- Waxing and waning course
- Common in the hospital
- Memory, orientation, perception, sleep, speech, consciousness and psychomotor hypo and hyper active or mixed changes. Cx: stress causes metabolic changes
- Vast differential diagnosis
- Medications
- Surgery
- Infection
- Dehydration
- Laboratory abnormalities
- Associated with other disease process, e.g., cancer, collagen vascular disease, MI, dem, dep
- Marked increase in mortality rate
- Treatment
- Treat the underlying problem
- Orientation strategies
Confusion in the elderly: depression
- 40% of elders experience depression
- Elders do not recognize (or acknowledge) their depression
- Elderly males are the highest suicide risk
- Depression more likely to lead to Parkinson’s dz, alzheimer’s disease, stroke
- s/p stroke: increased likelihood for major/minor depression
- Common symptoms
- Loss of energy and enthusiasm
- Sleep change: early morning awakening
- Weight loss
- Anxiety and perplexing
- Diagnosis: PHQ-2, PH!-9
- PHQ2: lack of interest, depressed mood? Yes to both is 83% sensitive!
- Treatment
- Medication
- Counseling
- Education
Depression sx
- Sleep – increased or decreased (if decreased, often early morning awakening)
- Interest – decreased
- Guilt/worthlessness
- Energy – decreased or fatigued
- Concentration/difficulty making decisions
- Appetite and/or weight increase or decrease
- Psychomotor activity – increased or decreased
- Suicidal ideation
Depression treatment
- 1) SSRI:primary treatment, risk of Serotonin syndrome
- Can cause impotence and weight gain
- 2)SNRI: better for neuropathic pain, eg. Remeron
- ***1 & 2: check Na in 2 wks if on other rx that effect ADH (diuretics NSAIDS, Monitor for GIB/nsaid/asa
- Can create problems with sodium metabolism
- 3) Buproprion: no sex SE, no weight gain no GIB.
- 4) TCAs: SE: anticholinergic, increase HR, orthostasis, monitor EKG!
Other depression treatments
- CBT: cognitive behavioral therapy
- PST: problem solving therapy
- TIP: treatment initiation and participation
- ECT: electroconvulsant therapy
Mental health issues of the elderly
- Loneliness
- Boredom
- Vulnerability
- Impaired Self-Assessment Skills
- Loss
- Home
- Loved Ones
- Respect of the Community
- Substance abuse
- Alcohol use/abuse
Alcohol and elders
- 5.6% Binge Drinking in the Last Month
- 2 Million Elders have Alcohol Issues
- High Risk Drinkers
- 15% Men
- 12% Women
- Stressful Life Events may be Triggers
Screening for alcohol use
- Ask!
- Laboratory Clues
- Gamma-glutamyl Transpeptidase (GGT) enzyme in liver that indicates liver dz
- Mean Corpuscular Volume (MCV) – size of the red blood cell
- Microcytic anemia is secondary to GI bleed
- Macrocytic anemia = depletion of folate and B12 à ALCOHOLICS!!
- Carbohydrate-deficient Transferring (CDT) 4-5 etoh proportion of transfer with fewer chains increased
- Screening: CAGE
- C: felt you should cut down
- A: been annoyed by others’ concerns
- G: feel guilty about your drinking
- E: ever taken a drink first thing in the morning as an eye-opener
Alcohol and aging
- Low-risk Drinking
- At-risk Drinking
- Alcohol Abuse
- Alcohol Dependence
Mental health of the elderly
- End of Life Issues
- Recognition of Time Limitations
- Hearing Bad News
- Accepting Bad News
- Preparing for Death
Capacity vs. Competence
- Capacity versus Competence
- Medical vs legal eg MDM capacity with DPOA
- Issue by Issue Determination
- Capacity Guidelines
- cognitive status
- ability to appreciate the problem and its consequences
- ability to discriminate risks versus benefits of treatments
Assessment of capacity
- Age
- Physical Health
- Activities of Daily Living
- Mental and Emotional Health
- Substance Abuse
- Acceptance of Services
- Financial Resources
- Environment
- Orientation
- Does the Client Understand…
- the Situation?
- The Potential Consequences of the Situation?
- Their Own Limitations in the Situation and the Alternatives Available?