Conditions Flashcards
Psychosis
an individual is experiencing a reality different to everyone else
Schizophrenia
Schizophrenia - disorder characterised by psychotic episodes and negative symptoms
- paranoid (most common) - dominated by positive symptoms (hallucinations & delusions)
- hebephrenic - thought disorganisation predominates
- catatonic - rare form characterised by one or more catatonic symptoms
- simple - rare form where negative symptoms develop without psychotic symptoms
Hallucinations
1) hallucinations
- perception of an object in the absence of an external stimulus
- 5 modalities - visual, auditory, gustatory, olfactory & tactile
- auditory is the most common in psychosis (2nd and 3rd: 3rd most likely for schizophrenia)
- check for organic pathology, eg. olfactory - frontal lobe pathology, visual - delirium
Delusions
2) delusions
- fixed, firmly held belief that is (usually) false, that cannot be reasoned away, that is held despite evidence to the contrary and is out of keeping with a person’s sociocultural norms
- different content - persecutory, grandiose, reference, erotomanic, hypochondriacal
Formal thought disorder
3) formal thought disorder
- a problem of speech which means that each sentence does not follow on from the next
Fragmentation of boundaries of the self
4) fragmentation of the boundaries of the self
- individual can no longer distinguish himself and the world
- thought broadcast - feelings are thoughts are heard out loud by others
- passivity phenomena - actions, feelings or emotions being controlled by an external force
- thought insertion - feelings that thoughts are being inserted
Negative symptoms
- avolition (decreased motivation) - reduced ability (or inability) to initiate and persist in goal-directed behaviour
- asocial behaviour - loss of drive for any social engagements
- anhedonia - lack of pleasure in activities that were previously enjoyable to the patient
- alogia (poverty of speech) - a quantitative and qualitative decrease in speech
- affected blunted - diminished/absent capacity to express feelings
- attention (cognitive deficits) - may experience problems with attention, language, memory and executive function
Schizophrenia investigations
Blood tests - FBC, TFTs, glucose/HbA1c, serum calcium, U&Es, LFTs, cholesterol, vitamin B12 & folate
Urine drug test
ECG
CT scan - rule out space-occupying lesions
EEG - rule out temporal lobe epilepsy
ICD-10 criteria for schizophrenia
ICD-10 criteria for schizophrenia:
- group A
- thought echo/insertion/withdrawal/broadcast
- delusions of control, influence or passivity phenomenon
- running commentary auditory hallucinations
- bizzare persistent delusions
- group B
- hallucinations in other modalities that are persistent
- thought disorganisation
- catatonic symptoms
- negative symptoms
- One clear symptoms from group A or two or more from group B for at least 1 month or more (DON’T DIAGNOSE in presence of organic brain disease)
Psychosis general management
First presentation of psychosis - early intervention in psychosis team: provide interventions targeted at reducing the duration of untreated psychosis
Psychosis biological management
- antipsychotics: typical and atypical
- atypical are first line
- depot formulations should be considered if patient prefers/problem with non-compliance
- clozapine is used for treatment-resistant schizophrenia (failure to respond to two other antipsychotics)
- adjuvants
- benzodiazepines can provide short-term relief of behavioural disturbance
- antidepressants and lithium can be used to augment antipsychotics
- ECT
- pts who are resistant to pharmacological agents
- effective for catatonic schizophrenia
Psychosis psychological treatment
- CBT - strongly recommended & reduces residual symptoms
- family intervention
- art therapy - alleviation of negative symptoms
- social skills training - behavioural approach to help patients improve interpersonal, self-care and coping skills needed in everyday life
Psychosis social management
- support groups
- peer groups - delivered by a peer support worker who has recovered from psychosis/schizophrenia & remains stable
- supported employment programmes
Depression
An affective mood disorder characterised by a persistent low mood, loss of pleasure and/or lack of energy accompanied by emotional, cognitive and biological symptoms
Depression core symptoms
- anhedonia - lack of interest in things
- low mood - present for at least 2 weeks
- anergia - lack of energy
Depression cognitive symptoms
- lack of concentration
- negative thoughts
- excessive guilt
- suicidal ideation
Depression biological symptoms
- diurnal variation in mood
- early morning wakening
- loss of libido
- psychomotor retardation - slow speech & slow movement
- weight loss & loss of appetite
Depression psychotic symptoms
- hallucinations - 2nd person auditory hallucinations
- delusions - hypochondriacal, guilt, nihilistic or persecutory in nature
Depression ix
- diagnostic questionnaires
- blood tests - FBC, TFTs, U&Es, LFTs, calcium levels, glucose
- imaging - MRI/CT scan
Depression staging
- mild depression = 2 core symptoms + 2 other symptoms
- moderate depression = 2 core symptoms + 3-4 other symptoms
- severe depression = 3 core symptoms + >3 other symptoms
- severe depression with psychosis = 3 core symptoms + >3 other symptoms + psychosis
Depression biological management
Antidepressants (not recommended as first-line for mild depression)
Adjuvants
ECT
Depression psychological management
Psychotherapies - CBT, IPT, behavioural activation, counselling, psychodynamic therapy
Self-help programmes - works through a self-help manual
Physical activity
Depression social management
Social support groups
Bipolar
Chronic episodic mood disorder, characterised by at least one episode of mania and a further episode of mania or depression
Bipolar aetiology
- genetics - strong FHx
- neurochemical - increased dopamine, increased serotonin
- endocrine - increased cortisol, increased aldosterone, increased thyroid
- adverse life events
- post-partum period
- loss of a loved one
Bipolar symptoms
- symptoms of mania or depression
- mania symptoms
- irritability
- disinhibited
- impaired insight
- grandiose delusions
- flight of ideas
- sleep decreased
- pressured speech
- elevated mood
Bipolar ix
- blood tests - FBC, TFTs, U&Es, LFTs, glucose, calcium
- urine drug test - illicit drugs
- CT head
Bipolar diagnosis
- requires at least two episodes in which a person’s mood and activity levels are significantly disturbed
- one of which must be mania/hypomania
Bipolar mx
Biological - mood stabilisers, benzodiazepines, antipsychotics, ECT (severe uncontrolled mania)
Psychological - psychoeducation, CBT
Social - social support groups, self-help groups, encourage calming activities
Patients who present with an acute episode should be followed-up once a week initially & then 2-4 weekly for the first few months
GAD
A syndrome of ongoing, uncontrollable, widespread worry about many events or thoughts that the patient recognises as excessive and inappropriate
- must be present on most days for 6 months
GAD aetiology
- biological
- genetics - concordance rate greater for monozygotic twins than dizygotic twins, 5-fold in GAD in first degree relative of patients of GAD
- neurophysiology - dysfunction of ANS, exaggerated responses in the amygdala and hippocampus
- environmental
- stressful life events, history of child abuse, problems with relationships, personal illness, employment/finances
- substance dependence/exposure to organic solvents
GAD risk factors
- predisposing
- genetics
- childhood upbringing
- personality type & demands for high achievement
- being divorced
- living alone/as a single parents
- precipitating
- stressful life events
- domestic violence
- unemployment
- relationship problems
- personal illness eg. chronic medical issues
- stressful life events
- maintaining
- continuing stressful events
- marital status
- living alone
GAD symptoms
- worry
- autonomic hyperactivity
- tension in muscles/tremor
- concentration difficulty/chronic aches
- headache/hyperventilation
- energy loss
- restlessness
- startled easily/sleep disturbance
GAD diagnosis
- period of at least 6 months with prominent tension, worry and feelings of apprehension about everyday events and problems
- at least four of the anxiety symptoms with at least one symptoms of autonomic arousal
- palpitations
- sweating
- shaking/tremor
- dry mouth
GAD mx
- biological
- first-line drug treatment of choice is an SSRI which has anxiolytic
- sertraline
- if this does not help, SNRI can be given
- if both of those cannot help → pregabalin
- medication should be continued for at least a year
- benzodiazepines should not be offered except as short-term measures
- first-line drug treatment of choice is an SSRI which has anxiolytic
- psychological
- psychoeducation groups
- CBT
- applied relaxation
- social
- self-help methods
- support groups
- exercise
Panic disorder
Characterised by recurrent, episodic, severe panic attacks which are unpredictable & not restricted to any particular situation or circumstance
Panic disorder aetiology
- biological
- one of the most heritable anxiety disorders
- post synaptic hypersensitivity to serotonin and adrenaline
- fear or worry stimulates the SNS → increased cardiac output which can lead to further anxiety
- cognitive
- misinterpretation of somatic symptoms
- environmental
- life stressors
Panic disorder risk factors
- family history
- major life events
- age (20-30)
- recent trauma
- females
- other mental disorders
- white ethnicity
- asthma
- cigarette smoking
- medication
Panic disorder symptoms
- palpitations
- abdominal distress
- numbness
- nausea
- intense fear of death
- choking feeling
- sweating
- shortness of breath
Panic disorder diagnosis
- recurrent panic attacks that are not consistently associated with a specific situation or object & often occur spontaneously → not associated with marked exertion/with exposure to dangerous or life-threatening situations
- all of the following:
- discrete episode of intense fear or discomfort
- starts abruptly
- reaches a crescendo within a few minutes and lasts at least some minutes
- at least one symptom of autonomic arousal
- other symptoms of anxiety
Panic disorder mx
- SSRIs are first line, TCA can be given if not suitable
- CBT
- Self-help methods: support groups and encouraging exercise
- Stepped care approach
Phobias
- phobia: an intense, irrational fear of an object, situation, place or person that is recognised as excessive or unreasonable
- agoraphobia: fear of public spaces or fear of entering a public space from which immediate escape would be difficult in the event of a panic attack
- social phobia: fear of social situations which may lead to humiliation, criticism or embarrassment
- specific phobia: a fear restricted to a specific object/situation
Phobias aetiology
- agoraphobia: maintained by avoidance which prevents deconditioning and sets up a vicious cycle of anxiety
- social phobia: uncertain aetiology
- specific phobia: conditioning event in early life, possibly a role for learned behaviour