conditions Flashcards
What is an organic illness
Conditions with demonstrable aetiology in CNS pathology
Causes of organic disorders
- substance misuse
- trauma
- inflammation
- degeneration
- infection
- metabolic
Examples of organic disorders
- Delirium
- Dementia
- Lobe syndrome
- Endocrine causes
List some organic causes of diseases
- Neurological
- Endocrine
- Metabolic
- SLE
- Medication
- Drug abuse
- Toxins
Neurological causes of psychosis
- epilepsy
- head injury
- brain tumour
- dementia
Endocrine causes of psychosis
- hyper/hypothyroidism
- cushing’s
- hyperparathyroidism
- addison’s disease
Metabolic causes of psychosis
- uraemia
- sodium imbalance
- porphyria (inherited blood disorder related to a build up in chemicals related to red blood cell proteins
Medications that can cause psychosis
- steroids
- L-dopa
- INH (isoniazid)
- anticholinergics
- antihypertensives
- anticonvulsants
- ritalin
Elicit drugs that can cause psychosis
- cocaine
- LSD
- cannabis
- PCP
- amphetamines
- opioids
Schizophrenia definition
Schizophrenia is the most common form of psychosis. It is a lifelong condition, which can take on either a chronic form or a form with relapsing and remitting episodes of acute illness
Schizophrenia epidemiology
Men are at higher risk of all psychotic disorders, ethnic minorities are at a higher risk of all psychotic disorders
Most commonly develops in adolescence and early 20s
Schizophrenia aetiology
multifactorial - genetic - environmental - social Short-lived illnesses similar to paranoid schizophrenia are associated with cocaine, amphetamines and cannabis
Schizophrenia risk factors
- family history
- intrauterine and perinatal complications eg. premature birth and low birth weight
- intrauterine infection
- abnormal early cognitive/neuromuscular development
- social isolation
- abnormal family interactions eg. hostile or overly critical
Schizophrenia presentation
First rank/positive symptoms
- delusions
- hallucinations
- thought disorder
- lack of insight
Chronic/negative symptoms
- underactivity
- low motivation
- social withdrawal
- emotional flattening
- self-neglect
Appearance and behaviour in schizophrenia
- withdrawal
- suspicion
- stereotypical behaviours eg. repetition of purposeless movements
- mannerisms eg. saluting
Speech in schizophrenia
- interruptions to the flow of thought
- loosening of associations
- loss of normal thought structure
Mood and affect in schizophrenia
- flattened
- incongruous or odd
Abnormal beliefs in schizophrenia
- hallucinations especially auditory
Cognition in schizophrenia
should assess attention, concentration, orientation and memory. Significant impairment suggests delirium or severe dementia
Schizophrenia differential diagnosis
- drug induced psychosis: amphetamine, LSD, cannabis
- temporal lobe epilepsy
- encephalitis
- dementia
- mania
- psychotic depression
- some personality disorders
Schizophrenia investigations
- LFTs and FBC for alcohol abuse
- serological tests for syphilis and AIDs screening
- urine screen for drugs of abuse
Schizophrenia management
Initial
- early assessment and engagement including assessment of social circumstances and involvement of family where possible
- early intervention is important
- antipsychotics can be prescribed. an atypical antipsychotic is normally used
MDT support in schizophrenia
combination of inpatient and outpatient care, hospital consultant, community psychiatric nurses, GPs, crisis support, daycare, home treatment teams, social workers, voluntary organisations and involvement of carers.
Psychological support for schizophrenia
- information and education
- voluntary organisations and support groups
information and support for carer - information and support for carers
- specialist “family interventions in psychosis” teams
- family therapy
- CBT
- art therapy
Drug management for schizophrenia
1st line
- atypical antipsychotics eg. risperidone or olanzapine
If violent or aggressive
- benzodiazepines for rapid tranquilisation
Side effects of antipsychotics
- weight gain
- extrapyramidal symptoms (dystonia, akathisia, parkinsonism, bradykinesia, tremor) are less common with atypical antipsychotics
Schizophrenia prognosis and recovery
- 80% show response to treatment in a year
- 20% have no new psychotic episodes within 5 years
- most live independently outside hospital
- 6.5% suicide risk
- reduced life expectancy by 10-20 years, linked to cardiovascular disease, respiratory disease and cancer
Factors associated with good prognosis in schizophrenia
- absence of family history
- good premorbid function (stable personality and relationships)
- clear precipitant
- acute onset
- mood disturbance
- prompt treatment
- maintenance of initiative and motivation
Factors associated with poor prognosis in schizophrenia
- longer duration of untreated psychosis
- early or insidious onset
- male
- negative symptoms
- family history
- low IQ, low socioeconomic status or social isolation
- significant psychiatric history
- continued substance misuse
What is schizoaffective disorder
A psychiatric condition which contains features of both schizophrenia and mood disorders (eg. depression, bipolar disorder)
Schizoaffective disorder epidemiology
- Less common than schizophrenia
- usually presents in early adulthood and women are more often affected
Types of schizoaffective disorder
- Bipolar type
- Depressive type
- Manic type
- Mixed type
Schizoaffective disorder diagnosis
- delusions or hallucinations must be present for at least two weeks when the mood symptoms are not present
- symptoms of mood disturbance are present for a significant length of the illness
- the disturbance must not be due to other causes eg. organic, substance misuse, medication
Schizoaffective disorder presentation
Can present as:
- major depressive episode
- manic episode
- mixed episode
- schizophrenia
How does a major depressive episode present
5 of the following for at least two weeks. One symptom must either be depressed mood or loss of interest or pleasure
- depressed mood
- decreased pleasure in activities
- weight loss/gain or appetite change
- insomnia or hypersomnia
- psychomotor agitation or retardation
- fatigue
- feelings of guilt or worthlessness
- decreased concentration
- recurrent thoughts of death or suicidal notions
How does a manic episode present
Persistent elevated or irritable mood for at least a week. 3 of following (or four if they have an irritable mood)
- inflated self esteem or grandiosity
- reduced need for sleep
- pressure of speech
- flight of ideas and racing thoughts
- easily distracted
- increase in goal-directed activity with psychomotor agitation
- excessive involvement in high risk activities eg. shopping sprees
How does a mixed episode present
contains features of both manic episode and major depressive episode
- you only need to have the symptoms for a week for diagnosis
Symptoms of schizophrenia for a diagnosis of schizoaffective disorder
2 or more for a month
- delusions (if bizarre, no other symptoms required)
- hallucinations (if in form of running commentary or 2 voices, no other symptoms required)
- speech abnormalities
- behavioural abnormalities eg. disorganised, catatonia
- negative symptoms eg. apathy or lack of emotions
Investigations for schizoaffective disorder
mainly to rule out underlying causes
- bloods eg. FBC, renal and LFT. TFT, HIV test
- urine or plasma toxicology
- CXR to exclude pneumonia in elderly
Schizoaffective disorder complications
- Poor social integration and function
- self-neglect
- difficulties with relationships
- substance misuse
- suicidal behaviour
- homicidal thoughts
Schizoaffective disorder management
- hospital admission, if threat to themselves or others Treatment of acute exacerbation - antipsychotics or atypical antipsychotics eg. risperidone, olanzapine Long term treatment - antipsychotics with psychological treatments Ongoing depressive symptoms - antidepressants - ECT In bipolar type - mood stabilisers Psychological treatments - CBT - family interventions - counselling - art therapy - supportive psychotherapy
Schizoaffective disorder prognosis
Bipolar type has better prognosis than depressive type due to long term mood disturbance
What is bipolar disorder
A chronic episodic illness associated with behavioural disturbances. Characterised by episodes of mania (or hypomania) and depression. Either can occur first, one may be more dominant, but all cases eventually lead to depression
Types of bipolar disorder
Type I: involves depression and mania. The manic episodes are severe, resulting in impaired functioning and frequent hospital admissions
Type II: just involves hypomania (mild form of mania). This has no psychotic symptoms and results in less associated dysfunction. Is often interspersed with depressive episodes
Bipolar disorder epidemiology
- 2.4% lifelong prevalence
- similar in men and women
- more common in 16-24 year olds
- type one slightly more common
- commonly associated with anxiety and substance misuse
Bipolar disorder presentation
- Manic phase
- Hypomanic phase
- Depressive phase
Describe the manic phase of bipolar disorder
- grandiose
- pressure of speech
- excessive amounts of energy
- racing thoughts and flight of ideas
- overactivity
- needing little sleep
- easily distracted
- bright clothes/unkempt
- increased appetite
- sexual inhibition
- recklessness with money
Describe the hypomanic phase of bipolar disorder
Lesser degree of mania
- persistent mild elevation of mood
- increased activity and energy
- no hallucinations or delusions
- no significant effect on functional ability
Describe the depressive phase of bipolar disorder
- low mood
- reduced energy
- no joy in daily activities
- have negative thoughts
- lack facial expressions
- poor eye contact
- tearful and unkempt
- low mood worse in mornings, disproportionate to circumstances
- feelings of despair, low self-esteem and guilt with no apparent reason
- weight loss
- reduced appetite
- altered sleeping pattern
- loss of libido
- in severe cases can be delusions of persecution or illness or impending death
- patients can become unwell through self-neglect