Concious Sedation Flashcards
Describe the mechanism by which quiet inspiration occurs?
Diaphragm and inspiratory muscles contract
Increases thoracic volume and therefore pressure decreases
Air is pulled inwards along a pressure gradient
How do you differentiate passive and forced expiration?
The involvedment of intercostal and expiratory muscles in forced expiration.
What parts make up vital lung capacity (VLC)?
Tidal volume (resting)
Inspiratory reserve volume (IRV)
Expiratory reserve volume (ERV)
What parts make up lung total lung capacity (TLC)?
Vital lung capacity (TV, IRV, ERV)
Residual volume (RV)
What is ventilation?
The volume of gasses passing between the lungs and air.
What is V:Q ratio?
The ratio of ventilation (the amount of gas in the lung) and perfusion (the amount that actually transfers between the alveoli.
What are Bohr shifts?
Any conidition or state which alters the natural Hb-O2 dissociation curve.
How is the breathing rhythm generated?
An automatic process of muscle contraction generated by respiratory centres in the brainstem.
What is the purpose of the SA node in the heart?
A natural pacemaker determining cardiac rhythm.
What is the AV node?
Receptor of signal from AV node, directs ventricles to contract via Purkinje system.
Which nervous systems innervate the heart?
Parasympathetic via vagus nerve, lowers heart rate and conduction.
Sympathetic via adrenoreceptors, elevates heart rate and cardiac output.
Outline what each of the PQRST waves on an ECG indicate.
P-wave: atrial depolarisation
QRS-wave: ventricular depolarisation
T-wave: ventricular repolarisation
How is blood pressure calculated?
Cardiac output x total peripheral resistance
CO x TPR
How do you calculate cardiac output?
Stroke volume x heart rate
SV x HR
Which factors determine stroke volume?
End diastolic volume
Ventricular contractility
Venous return
After load (TPR)
Which veins of the hand are targeted for canulation?
Basilic vein
Cephalic vein
What are the advantages of cannulating the hand?
Good access
No major anatomical structures nearby
What are the disadvantages of cannulating the hand?
Small veins
Susceptible to cold/anxiety
Mobile veins
More painful
What are the advantages to cannulating the cubital fossa?
Big well tethered veins
Less painful
Less vasoconstriction
What are the key aspects to consider in a sedation agent?
Anxiolysis (sedation)
Ease of administration
Non-irritant
Quick onset
Quick recovery
No side effects
Low cost
+/- amnesia
What is the mechanism by which benzodiazepines induce sedation?
Benzodiazepines have benzene ring which attaches to receptors in the CNS
Which mimics the effect of glyciene.
This enhances the effect of GABA, leading to sedation.
What clinical effects do benzodiazepines have?
CNS Depression and muscle relaxation
Decrease in cerebral response to CO2
Increase in respiratory depression in already compromised patients
Reduction in BP by reducing TPR
Increase in HR due to baroreceptor compensating for fall in BP
What are the potential side effects of benzodiazepines?
Drug interactions with any other CNS depressants, Erythromycin, and antihistamines.
Tolerance and dependence
Sexual fantasies
What were some of the drawbacks of diazepam when it was used as a sedation agent?
Long elimination half life
Metabolite half life
Risk of rebound sedation
Long recovery
Unpredictable
Painful upon injection
What advantages does midazolam have over diazepam?
Painless
Quicker onset
Quicker recovery
More reliable
What members of staff should be in attendance during sedation of a patient?
Operator
Secondary trained sedationist
Runner
Recovery area nurse
All must have appropriate training in sedation and managing emergencies resulting from sedation.
Why is an in-dwelling cannula mandatory for sedation?
May be needed to administer medications in an emergency.
Why is a butterfly cannula not advisable for sedation?
Higher chance of obstruction
Easily dislodged
What should be established during the assessment appointment for sedation?
Pre-op pulse and BP
Travel arrangements
Escort
Written informed consent
What should be monitored during sedation?
Sats (Pulse oximeter)
NIBP (Every 5-10 mins)
Allows for intervention before emergency
Why is high volume aspiration recomened for sedation procedures?
Patient may have difficulty swalling and breathing for themselves.
What is the purpose of flumazenil?
Reversal agent for benzodiazepines.
How should midazolam be given?
Through cannula, 2mg bolus to start, then 1mg incrimentally every 60 seconds until desired effect achieved.