Concepts of Cardiopulmonary Bypass Flashcards

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1
Q

Definition of a Perfusionist

A

A perfusionist is a certified medical technician responsible for extracorporeal oxygenation and flow of the blood during open-heart surgery and for the operation and maintenance of equipment (such as a heart-lung machine) controlling it.

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2
Q

Perfusionist Responsibilities

A
  • Setting up, operating and maintaining complex perfusion equipment
  • Monitoring circulation
  • Regulating the levels of oxygen and carbon dioxide in the blood
  • Regulating the body temperature
  • Measuring laboratory values such as arterial/venous blood gases
  • Administering medication and blood products via the bypass circuit under the supervision and direction of the anesthesiologist and surgeon
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3
Q

Circuit Components

A

♥ Oxygenator / Heat Exchange Unit
♥ Pump Head
♥ Venous Reservoir
♥ A-V Loop
♥ Arterial Filter
♥ Filtered Cardiotomy
♥ Cardioplegia Delivery System (MPS)
♥ Autologous Blood Conservation Technologies (Cell Saver)

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4
Q

Pump Prime

A

♥ Normosol
♥ 10,000 units Heparin
♥ 200 cc 25% Mannitol
♥ 50 mEq’s Bicarb
♥ 200 mg Lidocaine
♥ 80 mEq’s K+
♥ 5 grams Magnesium

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5
Q

What is the AV Loop?

A

♥ The AV Loop is the connection of the patients venous system to the patients arterial system with an extracorporeal circuit

♥ Venous cannula drains RA into the venous reservoir.

♥ Arterial line returns filtered blood through cannula which is inserted into the aorta

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6
Q

Cannulation Placement

A
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7
Q

Arterial Cannulation

A

♥Cannula inserted into ascending aorta to deliver oxygenated blood to the body

MUST BE BUBBLE FREE

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8
Q

Venous Cannulation

A

♥ 2-stage cannula inserted into right atrium. Basket in mid cannula sits in right atrium to drain upper body and basket at the tip sits in the inferior vena cava to drain the lower body

♥ Drainage is done by gravity but a vacuum can be added if necessary

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9
Q

Venous Reservoir

A

♥ Closed and open systems

♥ Defoamer, nylon sock, filtration media & screens

♥ Acts as the atrium of the heart-lung machine circuit

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10
Q

Venous Drainage

A

♥ 2-stage cannula inserted into the right atrium and connected to ½’’ pump tubing

♥ Drainage is achieved by gravity & vacuum

♥ Vaccum can be added to assist in drainage to gain more patient volume & empty the heart if needed

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11
Q

Venous O2 Saturation Monitor

A

♥ Constant in-line measurement of both venous O2 saturation and hct

♥ Good tool to tell whether adequate perfusion is being achieved

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12
Q

Which is a Better SVO2?

A

SVO2 50%
FIO2 100%
C.O. 3.0 LPM

B

SVO2 82%
FIO2 80%
C.O. 3.2 LPM

A

B

SVO2 82%
FIO2 80%
C.O. 3.2 LPM

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13
Q

Bubble Detector

A

♥ Safety mechanism which protects patient from receiving an air embolus

♥ Easily placed on any portion of pump tubing

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14
Q

E Clamp

A

The E Clamp is a safety device that is attached to the arterial line.

It’s function is to stop arterial flow to the patient when either air or low blood volume is detected

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15
Q

Pump Technology–Roller Pump

A

Positive Displacement

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16
Q

Pump Technology–Centrifugal pump

A

Centrifugal pump

♥ Non-occlusive constrained vortex
♥ Safer than roller pump
♥ Less traumatic to the formed elements of blood
♥ Maintains systemic circulation
♥ All pump types are hemolytic to some degree Hemolysis increases logarithmically over time.

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17
Q

Pump Console

A

♥ This is the “ Heart “

♥ Allows adjustment in raising or lowering blood flow. In other words managing patient’s cardiac output.

LPM!!!

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18
Q

Oxygenator–Heat Exchanger

A

♥ Integrated Hollow fiber membrane unit

♥ Stainless steel bellows heat exchange unit

♥ Plastic housing

♥ Urethane potting material

♥ Primary function is the oxygenation & removalof CO2 from blood.

♥ This is the “Lung”

♥ Secondary Function is blood temperature management

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19
Q

Heater Cooler

A

♥ Attaches to heat exchange on bottom of oxygenator

♥ Cools and warms patient via blood circulation

♥ Lowering 1 degree celsius reduces metabolic rate by
7%

♥ 3 types of hypothermia Mild, Moderate & Profound

20
Q

Sechrist O2 Blender

A

♥ Allows perfusionist to control the FIO2 and the delivery speed of the oxygen-air mixture to the oxygenator

♥ Mimics ventilator

21
Q

Desflurane / Isoflurane Vaporizer

A

♥ Provides continuous and easily titrateable level of
anesthesia

♥ Lowers chance of recall

♥ Allows heart to survive a longer period of time before injury due to ischemia. “Anesthesia Preconditioning”

♥ Quick On-Off properties due to its low blood gas solubility makes it very manageable to control BP

22
Q

Arterial Filter

A

♥ Arterial line includes 20 micron filter

♥ Removes air micro- and macro-bubbles via purge
line

♥ Blood in at top; exits out the bottom

Last safety device before blood enters patient

23
Q

Arterial Line Manometer

A

♥ Direct measurement of circuit line pressure

♥ Provides safety mechanism for the heart-lung machine by verifying proper placement of the aortic cannula and assuring that over-pressurization of the circuit does not occur

24
Q

Filtered Cardiotomy

A

♥ Following systemic heparinization pump suckers can be turned on & blood is scavenged to this filtered reservoir

♥ In open systems, the cardiotomy is integrated as a part of the venous reservoir instead of the collapsible bag

♥ Receives blood from the surgical field via pump suction

♥ Acts as backup reservoir when excessive volume is reached

♥ Receives volume when vents are put into the heart

25
Q

Aortic Root Vent

A

During bypass the aorta is cross clamped. Blood does manage to go through pulmonary circulation with 2 stage cannulation. If proper venting does not occur then LV distention results

26
Q

Left Ventricular-Pulmonary Vent

A

♥ Used on the valve replacement cases

♥ Mimics the same duties of the aortic root vent in limiting LV distention. “Starlings Curve”

27
Q

Delivery of Cardioplegia System

A

Cardiac arrest is achieved via high K+ infusion via the following routes:

  • aortic root
  • coronary sinus (retrograde)
  • vein grafts
  • coronary ostia
28
Q

Cardioplegia System

A

♥ High K+ infusion has a significant vasodilatory effect

♥ Magnesium helps membrane stability

♥ Quest Microplegia system allows “on the fly” adjustments

♥ Built-in heat exchanger to regulate the temperature of perfusate

29
Q

Major Benefit of Cardioplegia System

A

♥ Due to the fact that blood is used as the delivery solution instead of a crystalloid solution, hemodilution of the patient is significantly reduced

30
Q

Blood Gas Analyzer

A

♥ Gives results for the
following lab values:
PH, PCo2, PO2, Na+, K+,
Ca++, Glu, Lac, Hct, HCO3,
BE, SO2

♥ One located in each of the
heart rooms

31
Q

HepCon–Heparin Monitoring

A

♥ Prior to the patient being put on pump systemic heparinization must be reached

♥ Levels are measured every 30 minutes or as necessary to maintain an ACT of >480 sec.

32
Q

Autologous Blood Conservation Cell Saver

A

♥ Blood is heparinized as it is suctioned from the operative field.

♥ Suctioned blood is collected in a filtered reservoir.

♥ Filtered blood is centrifuged and washed with saline

♥ Washed RBC’s in normal saline is concentrated at Hct 50-75% and pumped to a transfusion bag.

♥ Large amounts of “cell saver” blood indicates large plasma loss.

33
Q

Major Disadvantage of Cell Saver

A

♥ Even though RBC’s are saved and returned to increase the patient’s Hct, all other formed elements of the patient’s blood are “washed” off, especially clotting factors. End result is potential bleeding problems with massive blood loss

34
Q

Arthrex Angel–Platelet Gel Machine

A

♥ AGF- Autologous Growth Factor

♥ Platelet “ RICH “

♥ Platelet “ POOR”

♥ Whole blood sample which is centrifuged to obtain these products

35
Q

Platelet “Rich” Application

A

Concentrated Platelets from whole blood sample. >1,000,000 platelets/ul

Contains 7 growth factors

Action is to stimulate and accelerate bone and soft tissue healing.

Safe and free from transmissible diseases like HIV and Hepatitis

Calcium & Thrombin added to produce gel formation.

36
Q

Platelet “POOR” Application

A

It contains mostly plasma with few platelets

Recommended for use in platelet aggregation

Applied on top of “RICH” to hold it in place like a bandage

37
Q

Protocol Summary

A

♥ Minimum Hct
- Cold – 21%
- Warm – 24%
♥ MAP 60-90mmHg
♥ Urine 1-2cc/kg/hr
♥ Temperature – Drift to 32 degrees Celsius♥ ABG’s q 30 minutes
♥ Document flows & U/O q 15 minutes
♥ Dose cardioplegia q 15-20 minutes
♥ Heparin / Protamine assays q 30 minutes
♥ Cell Saver all cases

38
Q

Words to Survive by in the Heart Room

A

Communication with all team members

Prepare for RAP procedure

Retrograde Cardioplegia Monitoring

Thumbs UP

Look over the drape and observe the heart and lungs

39
Q

Blood Contact Activation

A

♥ Contact Activation (Inflammation) - a series of host-defense
mechanisms designed to attack foreign substances or tissue
injury.

♥ CPB - results from blood coming in contact with plastic
tubing, filters, connectors, stainless steel heat exchangers,
and blood to gas interfaces

♥ Produces an overwhelming and systemic activation of the
inflammatory cascade. (Systemic Inflammatory Response
Syndrome: SIRS)

40
Q

Complement System & the Lungs

A

♥ The lungs are very susceptible to the inflammatory
processes.

♥ Activated WBC’s are deposited or sequestered in
the lungs; where they release superoxides and
lysosomal enzymes, which produce endothelial
damage & in turn results in the accumulation of
extravascular water. “PUMP LUNG”

41
Q

Awareness Of Reversing Heparin With Protamine

A

♥ Heparin-Protamine complex in human serum is
associated with activation of the classic pathway
and production of C3a,C4a and C5a.

♥ Severe hemodynamic compromise can result from
a particularly vigorous complement response
following protamine administration. “PROTAMINE
REACTION” GIVE IT SLOW!!!!!!!!!

42
Q

Air to Blood Interface Causes The Inflamatory Response

A

♥ Triggers blood contact activation.
♥ A primary rationale for the switch from early bubble
oxygenators to the present membrane oxygenators
♥ Formation of gaseous microemboli.
♥ These gaseous microemboli disrupt
microcirculation by producing tissue & organ
ischemia.

43
Q

Mechanisms to Reduce Blood Activation

A

♥ Closed venous reservoirs
♥ Bio-compatible surfaces
♥ Judicious use of suction, cell savers, vents
♥ Dosing the proper amount of heparin & protamine
♥“Microcircuitry” (Smaller Compact Circuits)

44
Q

Benefits Of Closed Venous Reservoirs

A

♥ Eliminates the majority of air/blood interface.
♥ Better flow dynamics, reduced areas of stasis.
♥ No defoaming agents, no nylon filter sock..
♥ Reduced complement activation.
♥ Preserves platelet function
♥ Reduced post-op bleeding.
♥ Improved post-op lung function.

45
Q

Benefits Of Bio-Compatible Surfaces

A

♥ Heparin bonded coatings. Tip to Tip
♥ Preserves Platelet Function
♥ Reduced complement activation
♥ Reduced post-op bleeding
♥ Improved post-op lung function
♥ Unfortunately, it’s only limitation is $$$$

46
Q

Summary

A

♥ Cardiopulmonary bypass is an unnatural physiological state that produces a whole-body inflammatory response

♥ If the cardiac surgical team fails to minimize blood
activation the results to the patient can be catastrophic.

♥ The thoughtful and meticulous application of available perfusion technologies can dramatically improve outcomes, length of stay and healthcare costs.