Complement System Controls Flashcards

1
Q

C1 Inhibitor (C1-INH)

A

Inactivates C1r and C1s,

MASP-1 and MASP-2

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2
Q

MCP

A

Cofactor for Factor-I mediated cleavage of C3b and C4b

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3
Q

DAF

A

Destabilizes C3/C5 convertase of CP and AP

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4
Q

CR1

A

Decay Acc. activity

Cofactor for Factor-I mediated cleavage of C3b and C4b

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5
Q

C4 Binding Protein (C4BP)

A

Binds to C4b

Decay Acc. activity

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6
Q

Factor H

A

Binds to C3b

Delay Acc. activity of AP C3 and C5 convertases

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7
Q

Factor I

A

Degrades C3b and C4b with help of cofactors

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8
Q

CD59

A

Blocks C9 association of C5b-8

Prevents MAC formation

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9
Q

S-protein (vitronectin)

A

Binds to C5b-7 and inhibits C9 polymerization

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10
Q

Clusterin

A

Binds to C5b-7 and inhibits generation of C5b-9

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