Complement System Controls Flashcards
1
Q
C1 Inhibitor (C1-INH)
A
Inactivates C1r and C1s,
MASP-1 and MASP-2
2
Q
MCP
A
Cofactor for Factor-I mediated cleavage of C3b and C4b
3
Q
DAF
A
Destabilizes C3/C5 convertase of CP and AP
4
Q
CR1
A
Decay Acc. activity
Cofactor for Factor-I mediated cleavage of C3b and C4b
5
Q
C4 Binding Protein (C4BP)
A
Binds to C4b
Decay Acc. activity
6
Q
Factor H
A
Binds to C3b
Delay Acc. activity of AP C3 and C5 convertases
7
Q
Factor I
A
Degrades C3b and C4b with help of cofactors
8
Q
CD59
A
Blocks C9 association of C5b-8
Prevents MAC formation
9
Q
S-protein (vitronectin)
A
Binds to C5b-7 and inhibits C9 polymerization
10
Q
Clusterin
A
Binds to C5b-7 and inhibits generation of C5b-9