Antibiotics Flashcards

1
Q

Streptomycin

A

Prokaryotic Translation Inhibtor

Binds to 30S subunit

Interferes with fmet-tRNA binding

Inhibits Initiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Clindamycin + Erythromycin

A

Prokaryotic Translation Inhibitor

Bind to 50S subunit

blocking translocation of ribosome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Tetracyclin

A

Prokaryotic Translation Inhibitor

Binds to 30S subunit

Blocks entry of amino acyl-tRNA

Impairs elongation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Chloramphenicol

A

Prokaryotic Translation Inhibitor

Inhibits peptidyl transferase activity

Impairs peptide bond formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Shiga Toxin + Ricin

A

Eukaryotic Translation inhibitor

Binds to large 60S subunit

Blocks entry of aminoacyl-TRNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Diphtheria Toxin

A

Eukaryotic translation inhibitor

Inactivates GTP-bound EF-2

Interferes with ribosomal translation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Cyclohexamide

A

Eukaryotic translation inhibitor

Inhibits peptidyl transferase,

impairs peptide bind formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Puromycin

A

Eukaryotic and Prokaryotic Elongation inhibitor

Resembles 3’ end of aminoacetylated tRNA

Resistant to hydrolysis, stops ribosome functioning

How well did you know this?
1
Not at all
2
3
4
5
Perfectly