Antibiotics Flashcards
Streptomycin
Prokaryotic Translation Inhibtor
Binds to 30S subunit
Interferes with fmet-tRNA binding
Inhibits Initiation
Clindamycin + Erythromycin
Prokaryotic Translation Inhibitor
Bind to 50S subunit
blocking translocation of ribosome
Tetracyclin
Prokaryotic Translation Inhibitor
Binds to 30S subunit
Blocks entry of amino acyl-tRNA
Impairs elongation
Chloramphenicol
Prokaryotic Translation Inhibitor
Inhibits peptidyl transferase activity
Impairs peptide bond formation
Shiga Toxin + Ricin
Eukaryotic Translation inhibitor
Binds to large 60S subunit
Blocks entry of aminoacyl-TRNA
Diphtheria Toxin
Eukaryotic translation inhibitor
Inactivates GTP-bound EF-2
Interferes with ribosomal translation
Cyclohexamide
Eukaryotic translation inhibitor
Inhibits peptidyl transferase,
impairs peptide bind formation
Puromycin
Eukaryotic and Prokaryotic Elongation inhibitor
Resembles 3’ end of aminoacetylated tRNA
Resistant to hydrolysis, stops ribosome functioning