Antibiotics Flashcards by Satyam Sharma | Brainscape

Q

Streptomycin

A

Prokaryotic Translation Inhibtor

Binds to 30S subunit

Interferes with fmet-tRNA binding

Inhibits Initiation

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Q

Clindamycin + Erythromycin

A

Prokaryotic Translation Inhibitor

Bind to 50S subunit

blocking translocation of ribosome

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Q

Tetracyclin

A

Prokaryotic Translation Inhibitor

Binds to 30S subunit

Blocks entry of amino acyl-tRNA

Impairs elongation

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Q

Chloramphenicol

A

Prokaryotic Translation Inhibitor

Inhibits peptidyl transferase activity

Impairs peptide bond formation

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Q

Shiga Toxin + Ricin

A

Eukaryotic Translation inhibitor

Binds to large 60S subunit

Blocks entry of aminoacyl-TRNA

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Q

Diphtheria Toxin

A

Eukaryotic translation inhibitor

Inactivates GTP-bound EF-2

Interferes with ribosomal translation

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Q

Cyclohexamide

A

Eukaryotic translation inhibitor

Inhibits peptidyl transferase,

impairs peptide bind formation

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Q

Puromycin

A

Eukaryotic and Prokaryotic Elongation inhibitor

Resembles 3’ end of aminoacetylated tRNA

Resistant to hydrolysis, stops ribosome functioning

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