Complement System Flashcards
Function of complement system
opsonisation
Chemotaxis
Cell lysis
Agglutination
What are the 3pathways of complement system
Classical
Lectin
Alternative
Classical pathway is activated by..
Antigen Ab complex
What activates the alternative pathway
The antigen
What is the C3 convertase of classical pathway
c4bC2b
What is MAC
Membrane attack Complex
Forms a hole in the surface of pathogen and cause lysis
Lectin pathway is activated by…
Mannan binding lectin
Alternative pathway is activated by..
The antigen directly
What is the C5 convertase in the alternative pathway
C3bBbP
What complement component attract neutrophils
C2a,C4aC5a C3a
What are the regulatory proteins of the complement cascade
C1 inhibitors
Factor H :inhibit alternative pathway
Factor I:inhibit all
Decay accelerating factor inhibit alternative pathway