Complement System Flashcards

1
Q

Function of complement system

A

opsonisation
Chemotaxis
Cell lysis
Agglutination

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2
Q

What are the 3pathways of complement system

A

Classical
Lectin
Alternative

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3
Q

Classical pathway is activated by..

A

Antigen Ab complex

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4
Q

What activates the alternative pathway

A

The antigen

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5
Q

What is the C3 convertase of classical pathway

A

c4bC2b

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6
Q

What is MAC

A

Membrane attack Complex

Forms a hole in the surface of pathogen and cause lysis

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7
Q

Lectin pathway is activated by…

A

Mannan binding lectin

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8
Q

Alternative pathway is activated by..

A

The antigen directly

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9
Q

What is the C5 convertase in the alternative pathway

A

C3bBbP

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10
Q

What complement component attract neutrophils

A

C2a,C4aC5a C3a

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11
Q

What are the regulatory proteins of the complement cascade

A

C1 inhibitors
Factor H :inhibit alternative pathway
Factor I:inhibit all
Decay accelerating factor inhibit alternative pathway

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