Comorbidities

Question 1

How does CV contribute to premature death in RA?

Answer 1

• inflamm in body - BV - vasculitis
• CRP - non specific marker of inflamm - increased risk CVD - elevated in RA

= aggressive management

1. systemic inflamm
2. traditional CVD rf - BP, choelstrol , smoking

Question 2

How does maligancy contribute to premature death in RA?

Answer 2

- 2nd most common 
Specific increased risk developing:
- lymphoproliferative malig - lymphoma, leukaemia multiple melonam 
- melanoma 
- lung cancer 

decreased risk of developing ?

• cervical + prostate cancer
• digestive tract

Question 3

How does infec contribute to premature death in RA

Answer 3

• older age
• disease activity
• concomittant conitions - renal failure / lung disease
• prolong glucocorticoid

Question 4

how does osteoperiosis contribute to premature death in RA?

Answer 4

• cytokines stimulate osteoclast
• inhibit osteoblast
• arthritis meds - bone loss