Communication And Homeostasis Flashcards
what is homeostasis
regulation of the internal conditions of a cell or organism to maintain optimum conditions for function
in response to internal and external changes
two types of communication system
endocrine + nervous
describe the effect of high pH on enzymes
Hydrogen + ionic bonds hold the tertiary structure together
solutions with an excess of H+ / OH– ions = cause these bonds to break
alters shape of active site
enzyme-substrate complexes form less easily
eventually, enzyme-substrate complexes can no longer form at all
complete denaturation
purpose of cell signalling
allows multicellular organisms to control and coordinate their bodies and to respond to their environments
describe the stages of cell signalling
A stimulus is received by a receptor cell
stimulus is converted to a signal - e.g chemical - that can be passed on
(this process = transduction)
signal is transmitted to target cell that can detect it via receptors in its cell membrane
An appropriate response is made
what is paracrine signalling
signalling between cells that are close together
what is endocrine signalling
signalling between cells that are far apart
being transported in the circulatory system
examples of paracrine signalling molecules
amino acids / lipids / phospholipids / glycoproteins
examples of endocrine signalling molecule
hormone
what is negative feedback
reduces initial effect of the stimulus
what is positive feedback
enhances the effect of original stimulus
state three examples of positive feedback
clotting cascade
childbirth
bone repair
describe the clotting cascade as a positive feedback cycle
Blood vessel damaged + platelets stick to region
Release factors that initiate clotting + that attracts more platelets
describe childbirth as an example of positive feedback
Head of baby pressed against cervix
Production of oxytocin
stimulates uterus to contract + baby head pushes even harder against cervix
more oxytocin – until baby born
describe bone repair as an example of positive feedback
involving special cells - osteoblasts and osteoclasts
osteoblasts secrete a hormone - inactive osteocalcin
osteoclasts secrete acid = causes the inactive osteocalcin to become active
active form of osteocalcin binds to a receptor on beta cells in pancreas
stimulates them to release insulin
Osteoblast possess insulin receptors + when stimulated causes them to release more inactive osteocalcin
osteoblast cells enhance the effect of the original stimulus (insulin) - positive feedback
Insulin is known to have anabolic effects, promoting the building of tissues, including bone