Commonly Used Vasoactive Agents Flashcards
B1, some B2 and a1 in large doses
Dobutamine
Inotrope only; Causes Hypotension in Volume depleted patients; less peripheral vasoconstriction than dopamine; fewer arrythmias than isoproterenol
Cardiac Contractility: ++++
Vasoconstriction: +
Vasodialtion: ++
Dobutamine
2.0 - 20.0 micrograms/kg/min
Dose of dopamine that causes vasodilation
Low dose
0.5-2.0 micrograms/kg/min
Cerebral, mesenteric, coronary, renal vasodilator
Dose of dopamine that results to increased cardiac contractility
Moderate dose
2.5 - 5 micrograms/kg/min
Dose of dopamine that results to vasoconstriction
5 - 20 micrograms/kg/min
This vasoactive drug causes leukocytosis, increased myocardial oxygen consumption, and lactate increase
Epinephrine
2-10 micrograms/min
0.5-8 micrograms/kg/min: ++++ Cardiac contractility
> 8 micrograms/kg/min: ++++ Vasoconstriction
+++ Vasodilation
Vasoactive drug with no vasoconstriction effects
Cadriac contractility and Vasodilation: ++++
Isoproterenol
0.01 - 0.1 microgram/kg/ming
SE:
Facial flushing
Hypotension in hypovolemic patients
increases myocardial O2 consumption
Vasoactive drug that has mostly vasoconstrictive effects with some increase in cardiac contractilty
Norepinephrine
0.5-50micrograms/min
Primarily a1 with some B1
Action of Phenylephrine
Pure alpha
10-200 micrograms/min
Purely vasoconstriciton
Decreases cardiac output
Vasoactive drug that causes reflex bradycardia
Phenylephrine
10-200micrograms/min
Used in shock with tachycardia or supraventricular arrhythmias
Not good for septic shock
other SE: Headache, restlessness, excitability, arrythmias (rarely)
This vasoactive is usually started at the max dose
Vasopressin
Dose: 0.01-0.04 units/min
Directly stimulates V1 receptor on smooth muscles
Typically added to norepinephrine
