Commonly Used Drugs for Specific Pathogens Flashcards
1
Q
Methicillin-susceptible Staphylococcus aureus (MSSA)
A
- Antistaphylococcal penicillins
- Amoxicillin/clavulanate
- Ampicillin/sulbactam
- 1st and 2nd gen cephalosporins
2
Q
Methicillin-resistant Staphylococcus aureus (MRSA)
A
- Vancomycin (consider using alternative if MIC ≥ 2)
- Linezolid
- Daptomycin (not in pneumonia)
- Ceftaroline
- SMX/TMP (CA-MRSA SSTIs)
- Doxycycline, minocycline (CA-MRSA SSTIs)
- Clindamycin (CA-MRSA SSTIs)
3
Q
Vancomycin-resistant Enterococcus (VRE)
A
- Pen G or ampicillin (E. faecalis only)
- Linezolid
- Daptomycin
- Cystitis only: nitrofurantoin, fosfomycin, doxycycline
4
Q
Atypical Organisms
A
- Azithromycin, clarithromycin
- Doxycycline, minocycline
- Quinolones
5
Q
C. difficile
A
- Fidaxomicin
- Vancomycin (oral)
- Metronidazole
6
Q
HNPEK
A
- Beta-lactam/beta-lactamase inhibitor
- Cephalosporins (except 1st gen)
- Carbapenems
- Aminoglycosides
- Quinolones
- SMX/TMP
7
Q
Gram-negative anaerobes (B. fragilis)
A
- Metronidazole
- Beta-lactam/beta-lactamase inhibitor
- Cefotetan, cefoxitin
- Carbapenems
- Moxifloxacin (reduced activity)
8
Q
Pseudomonas aeruginosa
A
- Piperacillin/tazobactam
- Cefepime
- Ceftazidime
- Ceftazidime/avibactam
- Ceftolozane/tazobactam
- Carbapenems (except ertapenem)
- Aztreonam
- Ciprofloxacin, levofloxacin
- Tobramycin
- Colistimethate, polymyxin B
9
Q
CAPES
Citrobacter, Acinetobacter, Providencia, Enterobacter, Serratia
A
- Piperacillin/tazobactam
- Cefepime
- Carbapenems
- Aminoglycosides
- Colistimethate, polymyxin B
10
Q
Extended-spectrum beta-lactamase (ESBL) producing gram-negative rods (E. coli, K. pneumoniae, P. mirabilis)
A
- Ceftazidime/avibactam
- Ceftolozane/tazobactam
- Carbapenems
11
Q
Carbapenem-resistant gram-negative rods (CRE)
A
- Ceftazidime/avibactam
- Meropenem/vaborbactam
- Imipenem/cilastatin/relebactam
- Colistimethate, polymyxin B
