Common Toxicities of Select Chemotherapeutic Agents

Question 1

Toxicity

Myelosupression

Answer 1

Almost all chemo drugs except: asparaginase, bleomycin, vincristine, and most MAbs

Manage neutropenia, anemia, and thrombocytopenia

Question 2

Toxicity

Nausea & Vomiting

Answer 2

Cisplatin, cyclophosphamide, ifosfamide, doxorubicin and epirubicin

Question 3

Toxicity

Mucositis

Answer 3

Fluorouracil, methotrexate, capecitabine, irinotecan, many TKIs

symptomatic treatment is done

Question 4

Toxicity

Diarrhea

Answer 4

Irinotecan, capecitabine, fluorouracil, methotrexate and many TKIs

For Irinotecan use atropine

Question 5

Toxicity

Constipation

Answer 5

Vincristine, pomalidomide, thalidomide

Question 6

Toxicity

Cardiomyopathy

Answer 6

Anthracyclines, HER2 inhibitors, and fluorouracil

Question 7

Toxicity

QT prolongation

Answer 7

Arsenic trioxide, many TKIs, leuprolide

Question 8

Toxicity

Pulmonary fibrosis

Answer 8

bleomycin, busulfan, carmustine, lomustine

Question 9

Toxicity

Pneumonitis

Answer 9

Methotrexate and MAbs targeting CTLA-4 or PD-1/PD-L1

Question 10

Toxicity

Hepatotoxicity

Answer 10

antiandrogens, folate antimetabolites, pyrimidine analog metabolites, many TKIs and some MAbs

Question 11

Toxicity

Nephrotoxicity

Answer 11

cisplatin, methotrexate, pemetrexed, pralatrexate, and some MAbs

Question 12

Toxicity

Hemorrhagic Cystitis

Answer 12

Ifosfamide, cyclophosphamide (high doses)

Question 13

Toxicity

Peripheral neuropathy

Answer 13

vinca alkaloids, platinums, taxanes, proteasome inhibitors, thalidomide

Question 14

Toxicity

Autonomic Neuropathy

Answer 14

Vinca alkaloids

Question 15

Toxicity

Thromboembolic risk

Answer 15

aromatase inhibitors, SERMs