Common Drug Toxicity

Question 1

Clozapine

Answer 1

Agranulocytosis

condition in which the absolute neutrophil count (ANC) is less than 100 neutrophils per microlitre of blood

Question 2

Chloramphenicol
NSAIDs
Benzene

Answer 2

Aplastic Anemia

occurs when your bone marrow cannot make enough new blood cells for your body to work normally

Question 3

Tricyclics
(-triptyline)
(-pramine)

Antidepressants

Answer 3

Atropine-like Side Effects

Question 4

Doxorubicin
Daunorubicin

Answer 4

Cardiotoxicity

Question 5

Fluoroquinolones
(Ciprofloxacin & Norfloxacin)

Answer 5

Cartilage Damage in children

Question 6

Quinidine

Answer 6

Cinchonism

Question 7

ACE Inhibitors
(-pril)

Answer 7

Cough

Question 8

Lithium

Answer 8

Diabetes Insipidus

Question 9

Metronidazole
Sulfonylureas (1st generation)

Sulfonylureas (1st generation)
> acetohexamide
> chlorpropamide
> tolazamide
> tolbutamide

Answer 9

Disulfiram-like effect

Question 10

Antipsychotics

> Thioridazine
Haloperidol
Chlorpromazine

Answer 10

Extrapyramidal Side
Effects

Question 11

Tetracycline
(-cycline)

Answer 11

Fanconi’s Syndrome

defect of proximal tubule leading to malabsorption

Question 12

Valproic Acid
Halothane
Acetaminophen

Answer 12

Fatal Hepatotoxicity
(necrosis)

Question 13

Phenytoin

Answer 13

Gingical Hyperplasia

Question 14

Chloramphenicol

Answer 14

Gray Baby Syndrome

Question 15

Cimetidine
Azoles
Spironolactone
Digitalis

Answer 15

Gynecomastia

Question 16

Sulfonamides
Isoniazid
Aspirin
Ibuprofen
Primaquine

Answer 16

Hemolytic Anemia in
G6PD-deficiency

Question 17

Isoniazid

Answer 17

Hepatitis

Question 18

Niacin
Tamoxifen
Ca++ Channel Blockers

Ca++ Channel Blockers
(-dipine)

Answer 18

Hot Flashes, Flushing

Question 19

Barbiturates
Phenytoin
Carbamazepine
Rifampin

Answer 19

Induce CP450

Question 20

Cimetidine
Ketoconazole

Answer 20

Inhibit CP450

Question 21

Methicillin
NSAIDs (except Aspirin)
Furosemide
Sulfonamides

Answer 21

Interstitial Nephritis

Question 22

Nitroglycerin

Answer 22

Monday Disease

loss of tolerance —-> headache, tach, dizziness upon re-exposure

Question 23

Rifampin

Answer 23

Orange Body Fluids

Question 24

Heparin
Corticosteroids

Answer 24

Osteoporosis

Question 25

Methyldopa

Answer 25

Positive Coombs' Test ## Footnote antibodies that act against your red blood cells

Question 26

Bleomycin Amiodarone

Answer 26

Pulmonary Fibrosis

Question 27

Vancomycin

Answer 27

Red Man Syndrome

Question 28

MAOIs ## Footnote > Isocarboxazid > Selegiline > Phenelzine

Answer 28

Severe HTN with Tyramine

Question 29

Procainamide Hydralazine

Answer 29

SLE-like Syndrome ## Footnote autoimmune phenomenon where the patient develops symptoms similar to systemic lupus

Question 30

Antipsychotics ## Footnote > Thioridazine > Haloperidol > Chlorpromazine

Answer 30

Tardive Dyskinesia ## Footnote isorder that causes involuntary facial tics like lip-smacking and grimacing

Question 31

Aspirin Quinidine

Answer 31

Tinnitus