Common Chemotherapeutic Agents

Question 1

Which (3) common chemotherapeutic agents are considered antimetabolites?

Answer 1

Methotrexate, 6-mercaptopurine (6-MP), and cytosine arabinoside (ara-C)

Question 2

Which (3) common chemotherapeutic agents are considered antibiotics?

Answer 2

Doxorubacin, daunorubacin, and bleomycin.

Question 3

What is a common chemotherapeutic agent in the family of alkylating agents?

Answer 3

Cyclophosphamide

Question 4

Which (2) common chemotherapeutic agents are considered vinka alkaloids?

Answer 4

Vincristine and vinblastine

Question 5

What enzyme is commonly used as a chemotherapeutic agent?

Answer 5

L-asparaginase

Question 6

What is the mechanism of action for methotrexate?

Answer 6

It is a folic acid antagonist.

Question 7

What is the mechanism of action for 6-mercaptopurine (6-MP)?

Answer 7

It inhibits purine synthesis.

Question 8

What is the mechanism of action for Cytosine arabinoside (ara-C)?

Answer 8

It inhibits DNA polymerase.

Question 9

What is the mechanism of action for Cyclophosphamide?

Answer 9

It inhibits DNA synthesis.

Question 10

What is the mechanism of action for Doxorubacin?

Answer 10

It binds to DNA.

Question 11

What is the mechanism of action for Daunorubacin?

Answer 11

It binds to DNA.

Question 12

What is the mechanism of action for Bleomycin?

Answer 12

It binds to DNA.

Question 13

What is the mechanism of action for Vincristine?

Answer 13

It inhibits microtubule formation.

Question 14

What is the mechanism of action for Vinblastine?

Answer 14

It inhibits microtubule formation.

Question 15

What is the mechanism of action for L-asparaginase?

Answer 15

It depletes L-asparagine.

Question 16

What is the mechanism of action for Cisplatin?

Answer 16

It inhibits DNA synthesis.

Question 17

What is the mechanism of action for Etoposide?

Answer 17

It’s a topoisomerase inhibitor.

Question 18

What are (3) common side effects associated with methotrexate?

Answer 18

Myelosuppression, renal toxicity, and hepatic toxicity.

Question 19

What are (2) common side effects associated with 6-mercaptopurine (6-MP)?

Answer 19

Myelosuppression and hepatotoxicity.

Question 20

What are (3) common side effects associated with Cytosine arabinoside (ara-C)?

Answer 20

Fever, systemic inflammation, and myelosuppression.

Question 21

What are (3) common side effects associated with Cyclophosphamide?

Answer 21

Hemorrhagic cystitis, secondary leukemias, and increased fertility with high doses.

Question 22

What is a common side effect of Doxorubacin?

Answer 22

Cardiomyopathy.

Question 23

What is a common side effect of Daunorubacin?

Answer 23

Cardiomyopathy.

Question 24

What is a common side effect of Bleomycin?

Answer 24

Pulmonary fibrosis.

Question 25

What is a common side effect of Vincristine?

Answer 25

Peripheral neuropathy.

Question 26

What is a common side effect of Vinblastine?

Answer 26

Leukopenia

Question 27

What are (3) common side effects associated with L-asparaginase?

Answer 27

Pancreatitis, hyperglycemia, and thrombosis.

Question 28

What are (3) common side effects associated with Cisplatin?

Answer 28

Nephrotoxicity, ototoxicity, and neurotoxicity.

Question 29

What is a common side effect of Etoposide?

Answer 29

The development of secondary leukemias.

Question 30

Methotrexate is commonly used in the treatment of which (4) diseases?

Answer 30

ALL, Non-Hodgkin lymphoma, osteosarcoma, and brain tumors.

Question 31

6-Mercaptopurine (6-MP) is commonly used in the treatment of which disease?

Answer 31

ALL

Question 32

Cytosine arabinoside (ara-C) is commonly used in the treatment of which (4) diseases?

Answer 32

ALL, AML, Hodgkin lymphoma, and Non-Hodgkin lymphoma

Question 33

Cyclophosphamide is commonly used in the treatment of which (9) diseases?

Answer 33

ALL, Hodgkin lymphoma, Non-Hodgkin lymphoma, Neuroblastoma, Wilms tumor, Rhabdomyosarcoma, Ewing sarcoma, Brain tumors, and Germ cell tumors.

Question 34

Doxorubacin is commonly used in the treatment of which (10) diseases?

Answer 34

ALL, Hodgkin lymphoma, Non-Hodgkin lymphoma, Neuroblastoma, Wilms tumor, Rhabdomyosarcoma, Osteosarcoma, Ewing sarcoma, Germ cell tumors, and Hepatoblastoma.

Question 35

Daunorubacin is commonly used in the treatment of which (2) diseases?

Answer 35

ALL and AML

Question 36

Bleomycin is commonly used in the treatment of which (2) diseases?

Answer 36

Hodgkin lymphoma and Germ cell tumors

Question 37

Vincristine is commonly used in the treatment of which (9) diseases?

Answer 37

ALL, Hodgkin lymphoma, Non-Hodgkin lymphoma, Neuroblastoma, Wilms tumor, Rhabdomyosarcoma, Ewing sarcoma, Brain tumors, and Hepatoblastoma.

Question 38

Vinblastine is commonly used in the treatment of which disease?

Answer 38

Hodgkin Lymphoma

Question 39

L-asparaginase is commonly used in the treatment of which (2) diseases?

Answer 39

ALL and AML

Question 40

Cisplatin is commonly used in the treatment of which (6) diseases?

Answer 40

Hodgkin lymphoma, neuroblastoma, osteosarcoma, brain tumors, germ cell tumors, and hepatoblastoma.

Question 41

Etoposide is commonly used in the treatment of which (12) diseases?

Answer 41

ALL, AML, Hodgkin lymphoma, Non-Hodgkin lymphoma, Neuroblastoma, Wilms tumor, Rhabdomyosarcoma, osteosarcoma, Ewing sarcoma, brain tumors, germ cell tumors, and HLH

Question 42

Prednisone/Dexamethasone are commonly used in the treatment of which (4) diseases?

Answer 42

ALL, Hodgkin lymphoma, Non-Hodgkin lymphoma, and HLH