Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PBR: Oncology > Common Chemotherapeutic Agents > Flashcards

Common Chemotherapeutic Agents Flashcards

1
Q

Which (3) common chemotherapeutic agents are considered antimetabolites?

A

Methotrexate, 6-mercaptopurine (6-MP), and cytosine arabinoside (ara-C)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which (3) common chemotherapeutic agents are considered antibiotics?

A

Doxorubacin, daunorubacin, and bleomycin.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is a common chemotherapeutic agent in the family of alkylating agents?

A

Cyclophosphamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which (2) common chemotherapeutic agents are considered vinka alkaloids?

A

Vincristine and vinblastine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What enzyme is commonly used as a chemotherapeutic agent?

A

L-asparaginase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the mechanism of action for methotrexate?

A

It is a folic acid antagonist.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the mechanism of action for 6-mercaptopurine (6-MP)?

A

It inhibits purine synthesis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the mechanism of action for Cytosine arabinoside (ara-C)?

A

It inhibits DNA polymerase.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the mechanism of action for Cyclophosphamide?

A

It inhibits DNA synthesis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the mechanism of action for Doxorubacin?

A

It binds to DNA.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the mechanism of action for Daunorubacin?

A

It binds to DNA.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the mechanism of action for Bleomycin?

A

It binds to DNA.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the mechanism of action for Vincristine?

A

It inhibits microtubule formation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the mechanism of action for Vinblastine?

A

It inhibits microtubule formation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the mechanism of action for L-asparaginase?

A

It depletes L-asparagine.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the mechanism of action for Cisplatin?

A

It inhibits DNA synthesis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the mechanism of action for Etoposide?

A

It’s a topoisomerase inhibitor.

18
Q

What are (3) common side effects associated with methotrexate?

A

Myelosuppression, renal toxicity, and hepatic toxicity.

19
Q

What are (2) common side effects associated with 6-mercaptopurine (6-MP)?

A

Myelosuppression and hepatotoxicity.

20
Q

What are (3) common side effects associated with Cytosine arabinoside (ara-C)?

A

Fever, systemic inflammation, and myelosuppression.

21
Q

What are (3) common side effects associated with Cyclophosphamide?

A

Hemorrhagic cystitis, secondary leukemias, and increased fertility with high doses.

22
Q

What is a common side effect of Doxorubacin?

A

Cardiomyopathy.

23
Q

What is a common side effect of Daunorubacin?

A

Cardiomyopathy.

24
Q

What is a common side effect of Bleomycin?

A

Pulmonary fibrosis.

25
Q

What is a common side effect of Vincristine?

A

Peripheral neuropathy.

26
Q

What is a common side effect of Vinblastine?

A

Leukopenia

27
Q

What are (3) common side effects associated with L-asparaginase?

A

Pancreatitis, hyperglycemia, and thrombosis.

28
Q

What are (3) common side effects associated with Cisplatin?

A

Nephrotoxicity, ototoxicity, and neurotoxicity.

29
Q

What is a common side effect of Etoposide?

A

The development of secondary leukemias.

30
Q

Methotrexate is commonly used in the treatment of which (4) diseases?

A

ALL, Non-Hodgkin lymphoma, osteosarcoma, and brain tumors.

31
Q

6-Mercaptopurine (6-MP) is commonly used in the treatment of which disease?

A

ALL

32
Q

Cytosine arabinoside (ara-C) is commonly used in the treatment of which (4) diseases?

A

ALL, AML, Hodgkin lymphoma, and Non-Hodgkin lymphoma

33
Q

Cyclophosphamide is commonly used in the treatment of which (9) diseases?

A

ALL, Hodgkin lymphoma, Non-Hodgkin lymphoma, Neuroblastoma, Wilms tumor, Rhabdomyosarcoma, Ewing sarcoma, Brain tumors, and Germ cell tumors.

34
Q

Doxorubacin is commonly used in the treatment of which (10) diseases?

A

ALL, Hodgkin lymphoma, Non-Hodgkin lymphoma, Neuroblastoma, Wilms tumor, Rhabdomyosarcoma, Osteosarcoma, Ewing sarcoma, Germ cell tumors, and Hepatoblastoma.

35
Q

Daunorubacin is commonly used in the treatment of which (2) diseases?

A

ALL and AML

36
Q

Bleomycin is commonly used in the treatment of which (2) diseases?

A

Hodgkin lymphoma and Germ cell tumors

37
Q

Vincristine is commonly used in the treatment of which (9) diseases?

A

ALL, Hodgkin lymphoma, Non-Hodgkin lymphoma, Neuroblastoma, Wilms tumor, Rhabdomyosarcoma, Ewing sarcoma, Brain tumors, and Hepatoblastoma.

38
Q

Vinblastine is commonly used in the treatment of which disease?

A

Hodgkin Lymphoma

39
Q

L-asparaginase is commonly used in the treatment of which (2) diseases?

A

ALL and AML

40
Q

Cisplatin is commonly used in the treatment of which (6) diseases?

A

Hodgkin lymphoma, neuroblastoma, osteosarcoma, brain tumors, germ cell tumors, and hepatoblastoma.

41
Q

Etoposide is commonly used in the treatment of which (12) diseases?

A

ALL, AML, Hodgkin lymphoma, Non-Hodgkin lymphoma, Neuroblastoma, Wilms tumor, Rhabdomyosarcoma, osteosarcoma, Ewing sarcoma, brain tumors, germ cell tumors, and HLH

42
Q

Prednisone/Dexamethasone are commonly used in the treatment of which (4) diseases?

A

ALL, Hodgkin lymphoma, Non-Hodgkin lymphoma, and HLH

PBR: Oncology (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions