Common bacterial pathogens 3 Flashcards
neisseria gonorrhoeae typically infects what two areas
mucous memranes (vag) and conjunctivitis (blindness in infants)
whats a protective resopnse to gonorrhoaeae
pills BUT antigenic variation so hard
prolonged gonorrhoaeae infections lead to what
scarring and fibrosis
gonorhoaeae in men
asymptomatic to urethritis
gonorrhoeae in females
infection of crevice and urethra and can climb up uterine tubes to cause fibrosis and infertility and is more often asymptomatic than males
pilus in gonorrhoaeae is important for
adherence and interfering with neutrophil killing
neisseria gonorrhoaeae is almost ALWAYS resistant to what and is usually resistant to 2 other things
always- penicillin, cephalosporins and fluroquinolone
prototypical endogeneous anaerobic pathogen
bacteroides fragilis
what bacteria is associated with over 80% of intra abdominal infections
bacteroides fragilis
bactericiodes common to oral cavity are associated with
anaerobic infections above diaphragm
how does bactericides fraigilis feel about oxygen
aerotolerant
what causes rocky mountain spotted fever
rickettsia
how does rickettsia get ATP
can’t make its own- requires on infected host cell
chalmidia trachnomatisis is what class of bacteria
obligate intracellular
2 diseases caused by chalmydia
trachoma and genital infections
trachnoma is what and where is it a problem
conjuctiva infection that causes scarring and blindness and is endemic in africa and asia
chlamydia is often found in co infections with what
n. gonorrhoeae
men with chlamydia how do they present
non gonococcal urethritis
3 things women get from chlamydia
PID, urethritis, cervicitis
2 diseases that chlamydia gives neonate
conjunctivitis and pneumonia
most common causes of pneumonia ages 5-20
mycoplsama pneumoniae
how severe is mycoplasma pneumonia
mild
mycoplasma adheres to ____ and growth is ____
respiratory epithelial cells and extracellular
how does mycoplasma pneumonia get transmited
infected respiratory secretions
mycoplsama pneumonia sypmtoms
fever, headache, sore throat, NON PRODUCTIVE COUGH, chest/body aches, fatigue
resolution of mycoplasma pneumonia is what temp
1-4 weeks
how do you treat mycoplasma pneumonia (or what NOT to use)
they DONT have cell wall aka don’t use penicillins
diagnosing mycoplasma pneumonia
culture is really hard (has to be in a cell free medium?) so use serum test or pcr
what bacteria doenst stain with gram stain
mycoplasma pneumonia because doesn’t have cell wall
2 virulence factors of mycoplasma pneumonia
hydrogen peroxide and superoxide radicals
toxic LPS moiety
Lipid A
smaller doses of LPS lead to what via whyat cytokines
fever and shock IL1 and TNF
larger doses of LPs lead to what 3 things
hypotension, hemorrhage, intracascular coagulatin
3 ways LPS gets released from cell wall fragments
antibiotic treatment, injecting contaminated materials, bacteremia
gram - membrane is a permeability barrier that protects the cell from some antibiotics like
erythromycin
superantigens do what
nonspecific T cell activation with MASSIVE CYTOKINE release
Big 3 to think about for empiric use of antibiotics
MRSA, pseudomonas, anaerobes
3 organisms most commonly responsible for bacterial endocarditis
S. aureus, strep viridans, coagulase negative staphylococci (like S epidermidis)
when you think endospores think of this pathogen
clostridiuj
infectious anaerobes are usually from where
endogenous
typical anaerobic lesion i swhat
abscess
hallmark of anaerobic lesion is
mixed infection
rickettsia and chlamydia are what class
obligate intracellular bacteria
2 genera of bacteria that lack cell walls and have sterols in plasma membrane
mycoplasma and ureaplasma
