Common ADRs

Question 1

ABx ADRs

1. Gent and Vanc

Answer 1

ABx ADRs

1. Gent and Vanc
   - Nephrotoxic
   - Ototoxic

Question 2

HTN Dx ADRs

• ACEi
• Beta-blockers
• CCBs
• Diuretics

Answer 2

HTN Dx ADRs

• ACEi
  1. Hypo tension
  2. Electrolytes
  3. AKI
  4. Cough
• Beta-blockers
  1. Hypotension
  2. Bradys
  3. Wheeze
  4. Acute HF (helps in chronic)
• CCBs
  1. Hypotension
  2. Brady
  3. Peripheral oedema
  4. Flushing
• Diuretics
  1. Hypotension
  2. Electrolytes
  3. AKI
  4. Specific effects

Question 3

Antithrombotics: ADRs

• Heparins
• Warfarin
• Aspirin

Answer 3

Antithrombotics: ADRs

• Heparins
  1. Haemorrhage (in renal failure, underweight)
  2. H induced thrombocytopaenia
• Warfarin
  1. Bleed
  2. Clot (bridging required)
• Aspirin
  1. Bleed
  2. Ulcers and gastritis
  3. Tinnitus (high dose)

Question 4

Rhythm drug ADRs

1. Digoxin
2. Amiodarone

Answer 4

Rhythm drug ADRs

• Digoxin
  1. N, V & D
  2. Blurred vision
  3. Confusion/drowsiness
  4. Xanthopsia (yellow/green/halo)
  5 Dependant on K+ levels
• Amiodarone
  1. ILD (pulm fib)
  2. Thyroid disease
  3. Skin greying
  4. Corneal deposits

Question 5

Lithium
- ADRs

Answer 5

Lithium
- ADRs

LI - Leucocyte increase

T - Tremors
H - Hypothyroid

IU - Increased urine (diabetes insipidus)
M - Malformation (ebstein’s)

Question 6

NSAID ADRs

Answer 6

NSAID ADRs

N- No urine (AKI)
S - Systolic dysfunction (HF)
A - Asthma
I - Indigestion
D - Dyscrasia