COMLEX Cases

Question 1

This is an AD disorder that presents with recurrent severe epistaxis episodes, multiple telangiectasias, and arteriovenous malformations.

Answer 1

Osler-Weber-Rendu syndrome

Question 2

Patient with HTN, loss of muscle mass, hirsutism, and weight gain. Anterior chapmans point found 2 inches superior and 1 inch lateral to umbilicus. High dose dexamethasone suppression tests lowered urinary cortisol levels. What is her disease and what organ pathology does this cause?

Answer 2

This is Ant Pituitary tumor secreting CRH. This causes hypertrophy of zona fasciculata.

You know this b/c a high dose dethamethasone test will only lower the cortisol lvls if it is a pituitary tumor. If it were an adrenal tumor, it would NOT be lowered.

Question 3

Name the pathological correlations with the following blood types:

Type A
Type B
Type AB
Type O

Answer 3

Type A - Gastric tumors

Type O - Peptic ulcers

Rest have no associations

Question 4

What is the specific AA mutation for sickle cell? How is it treated? What organisms are associated with causing osteomyelitis in SCD patients?

Answer 4

The normal glutamic acid is switched for valine due to point mutation.

Tx: Hydroxyurea

Salmonella > E. coli > others (consider them asplenic and encapsulated G- bact are risks)

Question 5

The following cancer markers are associated with what cancers?

CA 19-9:

CA-125:

Answer 5

CA 19-9 = Pancreatic adenocarcinoma

CA-125 = ovarian CA

Question 6

This is a DMARD (anti-RA drug) that causes retinal deposits as a SE

Answer 6

Hydroxycholorquine