COMBINED PSW I and 2 Flashcards
Px
concentration of x in the plasma
RPF
renal plasma flow
V
urine flow rate
Ux
concentration of substance x in the urine
using the Fick principle: RPF=
UxV/ (Pxa-Pxv)
Rate of Filtration (Fx)=
Plasma concentration (Px) x GFR
Rate of excretion (E)=
UxV
Rate of reabsorption (R)=
F-E
Rate of secretion (S)=
E-F
Fraction excretion (FE)=
E/F
Fraction reabsorption (FR)=
1-E/F
Clearance (C)=
UV/P
Clearance definition
the volume of plasma cleared of a substance per unit of time
what substance is completely excreted? What can we say about it?
Inulin, F=E
what do we use in the clinic to measure GFR?
creatinine
the normal level of creatinine in the blood is:
1 mg/dl
what is a substance that is completely secreted and not reabsorbed? What can it measure?
PAH, blood flow to the kidneys
Clearance of Creatinine (Ccr) can be used to estimate
GFR
Estimate of eRPF
Clearance of PAH
normal Tm for glucose
375 mg/min
normal renal threshold for glucose
180-200 mg/dL
Filtered load
= Plasma concentration x GFR