Combank 3 Flashcards
Name the two causative agents of tinea capitis and state which one fluoresces under wood light.
Microsporidium canis and Trichophyton tonsurons; Microsporidium canis fluoresces under wood light
Name this fungus - dimorphic fungus, part of normal skin flora in some, exists both as mold form and lipophilic yeast; known as spaghetti and meatballs
Malassezia furfur
What agents are used to treat Malassezia furfur?
topical ketoconazole or selenium sulfide
Name the fungus - dimorphic fungus that causes systemic disease, presents a severe pneumonia and skin ulcerations
Blastomyces dermatitidis
What is Blastomyces dermatitidis treated with?
itraconazole
Name the bacterium: gram positive, rod shaped, anaerobic, sulfur granules
Actinomyces israelii
What is actinomyces israelii treated with?
penicillin G
What is Trichophyton tonsurans treated with?
griseofulvin or terbinafine
What should you suspect as the cause of tinea capitis if an African American child presents with patchy hair loss which leaves black dots on the scalp?
Trichophyton tonsurans
Name the bacterium: gram positive filamentous bacteria, partially acid fast, STRICT AEROBE, produces abscesses in the lungs
Nocardia asteroides
DOC for Actinomyces israelii
Penicillin
Treatment of choice for Nocardia asteroides
Trimethoprim/sulfamethoxazole
What is the treatment of choice for Coxiella burnetii
Doxycycline
What is the treatment of choice for Bordetella pertussis?
Erythromycin
Aminoglycosides are used on what type of gram stained infections?
severe gram negative infections
T/F Aminoglycosides are ineffective against anaerobes
T
Name some other catalase positive bacteria other than staph
Serratia, Pseudomonas, Actinomyces (most), Candida, E. coli
In staphylococcal scalded skin syndrome does the bullae contain organisms?
NO
In bullous impetigo (a localized form of staph scalded skin syndrome) does the fluid filled blisters contain bacteria?
YES
How does the cholera toxin work?
stimulates a stimulatory G protein in order to increase adenylate cyclase, this causes the release of more chloride into the gut lumen and the decreased resorption of sodium. Resulting electrolyte imbalance leads to loss of water from cells
How does pertussis toxin work?
inhibits an inhibitory G protein, leading to increased intracellular cAMP
How does the AB toxin of Vibrio cholerae work?
ADP ribosylates a stimulatory G protein, this turns the stimulatory G protein on, leading to rice water stools
Both Shigella and EHEC produces a toxin that ..
inactivates 60s ribosomes, leading to decreased protein synthesis of the host cell
How does the Clostridium tetani toxin called tetanospasmin work?
blocks the release of inhibitory neurotransmitters GABA and glycine leading to spastic muscle paralysis
Which two bacteria both produce toxins that ADP ribosylates elongation factor-2 causing inactivation of this enzyme, leading to inhibition of protein synthesis and death?
Corynebacterium diphtheriae and Pseudomonas aeruginosa