Colorectal surgery Flashcards
Small bowel obstruction causes
Hernia
Adhesions
Tumour
Large bowel obstruction causes
Cancer
Volvulus
Strictures (diverticular disease > IBD)
Obstruction Ix
AXR
Definitive: CT abdomen
Colorectal cancer S+S
Change in bowel habit PR bleeding WL Fatigue Anaemia - more likely a R sided colorectal cancer if this is found (more indolent bleeding)
Colorectal Ca Ix
Sigmoidoscopy –> colonoscopy
Screening
55y = flexi sig –> colonoscopy if +
- Once
- Male and female
60-74 = faecal immunochemical test
- every 2 years
- male and female
- if +ve, colonoscopy is offered
Colorectal Ca Mx
- Resection (sigmoid colectomy is not a cancer operation – need to take the entire IMA for all lymph supply)
- Heparin SC enoxaparin for 28d
± pre-operative (neoadjuvant) chemoradiotherapy if pelvic LN spread
Colorectal Ca post-op complications
Ileus - peristalsis halted - fluids stop moving in intestine - electrolytes diffuse into lumen –> low electrolytes in blood and dehydrated pictures despite positive fluid balance
Anasamotic dehiscence – day 6, fever, septic
Ileus Mx
NG + IV fluids
Blood supply to the large bowel
IMA splits into Left colic artery
SMA splits into R colic artery –> ileocolic and middle colic arteries
3 areas of bowel with poor perfusion
R colon - vulernable in systemic low flow states as marginal artery of Drummond is poorly develop in 50% of population
Splenic flexure - marginal artery of Drummond is tenuous here/ absent in 5%
Rectosigmoid junction - distal to last collateral connection with proximal arteries
Syndromes associated with colorectal cancer
Familial adenomatous polyposis
MYH associated polyposis
Peutz Jegher’s syndrome
Cowden disease
HNPCC
FAP inheritance pattern
AD
FAP features
> 100 colonic adenomas
Cancer risk of 100%
20% are new mutations
FAP screening and Mx
Risk –> predictive genetic testing as teenager
Annual flexi-sig from 15 years
No polyps found –> 5 yearly colonoscopies from 20yo
Polyps found = resection
FAP associated disorders
Gastric fundal polyps (50%)
Duodenal polyps 90%
If severe duodenal polyposis cancer risk of 30% at 10y
Abdominal desmoid tumours
MYH associated polyposis inheritance pattern
AR
MYH associated polyposis features
Multiple colonic polyps
Later onset right sided cancers more common than in FAP
100% cancer risk by age 60
MYH associated polyposis Mx
Resection and ileoanal pouch
Attenuated phenotype –> regular colonoscopy
MYH associated polyposis associations
Duodenal polyposis in 30%
Associated with increased risk of breast cancer
Peutz-Jegher’s syndrome inheritance pattern
AD
Peutz-Jegher’s syndrome features
Multiple benign intestinal hamartomas
Episodic obstruction / intussusception
Risk GI cancers (CRC 20%, gastric 5%)
Increased risk of breast, ovarian, cervical pancreatic and testicular cancers
Peutz-Jegher’s syndrome Ix Mx
Annual examination
Pan intestinal endoscopy every 2-3 years
Peutz-Jegher’s syndrome associations
Malignancies at other sites
Pigmentation pattern
Cowden disease inheritance pattern
AD