Colorectal Cancer Flashcards
Where does colorectal cancer start?
Colon or rectum
1 in how many will develop colorectal cancer?
1 : 20
What gender is more at risk?
Men
Most common over what age?
50
Incidence rises with increasing age
Nearly all of colorectal start of as?
Polyps
What are polyps?
Small vascular growths on the mucous membrane (in the glandular tissue of intestinal lining)
Where do most tumors develop ?
Sigmoid colon or rectum
What are hyperplastic polyps?
Generally harmless, small
What are adenomatous polyps?
Common: small tumor of epithelial tissue
What does most colorectal cancer from from?
Adenomatous — > Adenocarcinomas
What are polypsosis syndromes?
Hereditary conditions which cause polyps
Usually rare, occurs in young people
High chance of becoming cancerous
What are some risk factors of colorectal cancer?
- Personal or family history of colorectal cancer, polypsosis disorders, inflammatory bowel disease
- Age >50
- Smoking
- Obesity
- Alcohol
- Radiation exposure
- Diets high in calories, fats, and meat proteins
- Presence of anaerobic gut bacteria
What is key in prevention of colorectal cancer?
Screening
For individuals over 50, what should they do for prevention?
- Yearly fecal occult blood test
- Stool DNA test
- Flexible Sigmoidoscopy every 5 year
- Double contrast barium enema every 5 years
- Colonoscopy every 10 years
- CT colonography every 5 years
- *MAY reduce incidence: exercise, MVI, aspirin, NSAIDS
What is the initial manifestation to seek care?
Rectal bleeding
Clinical manifestations of colorectal cancer?
Changes in bowel habits Pain Anorexia/weight loss Abdominal mass Fatigue Anemia
What are some diagnostic tools/tests used for colorectal cancer?
- Endoscopy (Full colonoscopy better than sigmoidoscopy- can detect 50-65%)
- Biopsy of tissue
- Fecal blood tests
- CBC
- Carcinoembryonic Antigen (CEA)
What can CEA be used for?
Monitor course of treatment, prognosis
*Detect possible areas of metastasis