Colorectal Cancer

Question 1

Anemic looking patient with classic colon cancer signs - CBC done - what is the next steP?

Answer 1

colonoscopy

Question 2

Development of colorectal cancer process

Answer 2

multistep process - activation of oncogenes and loss of tumor suppressors (4 hit hypothesis)

Question 3

**Whcih genes and order lost to develop colorectal cancer?

Answer 3

**APC, K-ras, DCC, p53

Question 4

Most common polyp type?

Answer 4

tubular adenoma

Question 5

Age of onset for:
FAP
-HNPCC
-FAS

Answer 5

-EARLY-
EARLY
-LATE

Question 6

Number of adenomas:
FAP
-HNPCC
-FAS

Answer 6

> 100 - <10 - 0-100

Question 7

Adenoma distribution
for:
FAP
HNPCC
FAS

Answer 7

• LEFT or total
• MAINLY RIGHT SIDE
• MAINLY RIGHT SIDE

Question 8

Cancer distribution for adenomas
FAP
HNPCC
FAS

Answer 8

random
mainly right side
mainly right side

Question 9

Other associated cancers:
FAP
HNPCC
FAS

Answer 9

periampullary
endometrial
periampullary

Question 10

TNM classification:

Answer 10

0=high grade dysplasia
1=beginning to work through the wall - mucosa submucosa 
2=through GI wall but NO LN
3=through entire GI wall and INTO LN
4= mets into other organs - liver, lungs

Question 11

HNPCC - signs symptom age

Answer 11

early age
multifocal
high grade often in right colon

Question 12

Is UC or CD higher risk for CRC?

Answer 12

UC has highe rrisk

Question 13

Adenocarcinoma presentation on CT?

Answer 13

apple core - constricting

Question 14

40 yo Patient is hypochromic and has microcytic anemia -diagnosis?

Answer 14

colon cancer until proven otherwise