Colorectal cancer

Question 1

What inherited conditions predispose to colorectal cancer?

Answer 1

Hereditary non-polyposis colorectal cancer (lynch syndrome) - autosomal dominant
Familial adenomatous polyposis - autosomal dominant
Peutz-Jeghers syndrome - associated with pigmented lesions in the buccal mucosa and lips, autosomal dominant

Question 2

Amsterdam Criteria for HNPCC
(Rule of 3-2-1-exclude-confirm)

Answer 2

3 relatives with colorectal cancer (with one being 1st degree relative)
2 generations of colorectal cancer
1 colorectal cancer before age 50
FAP excluded
Tumour confirmed by histopathology