Collagen

Question 1

Collagen

Answer 1

Most abundant protein in the human body.

Extensively modified by post translational modification

Organizes and strengthens extracellular matrix

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Question 2

Type I Collagen

Answer 2

Most common (90%)—*Bone (made by osteoblasts), *Skin, *Tendon, dentin, fascia,
cornea, late wound repair.

Type I: bone.
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DEC production in *osteogenesis imperfecta type I.

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Question 3

Type II Collagen

Answer 3

*Cartilage (including hyaline), vitreous body, nucleus pulpous

Type II: cartwolage

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Question 4

Type III Collagen

Answer 4

*Reticulin—skin, *blood vessels, uterus, fetal
tissue, granulation tissue

Type *III: deficient in the uncommon

vascular type of Ehlers-Danlos syndrome (ThreE D)

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Question 5

Type IV Collagen

Answer 5

*Basement membrane, basal lamina, lens

Type IV: under the floor (basement membrane)

Defective in Alport syndrome; targeted by autoantibodies in Goodpasture syndrome

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