Cognitive Disorders

Question 1

Role of Donepizil and Alzheimer’s?

Answer 1

Alzheimer’s associated with loss of cholinergic neurons.

Donepizil acts as an acetylcholinesterase inhibitor, which SLOWS (but does NOT REVERSE) memory loss.

Question 2

Normal pressure hydrocephalus

Clinical features?

Treatment?

Answer 2

Failure of CSF drainage leading to dilation of ventricles.

Triad (“wet, wobbly, wacky”): incontinence, gait instability, dementia,

May reverse with shunting.