Coenzyme And Cofactor

Question 1

What are cofactors

Answer 1

A cofactor is a small non protein molecules that is boun either tigthly Or losely to an enzyme and is required for catalysis
Catalytic activity of many enzymes depends on the presence of cofactors

Question 2

What are cofactors classified into

Answer 2

Cofactors are classified into Essential ions ( inorganic) and coenzymes ( organic)
Essential ions are classified into as activator ions ( Loosely bound) or metal ions of metalloenzymes
Coenzymes are divided into cosubstrates( losely bound) and prostate groups ( tigthly bound)

Question 3

What are activator ions

Answer 3

Activator ions bind Reversibly to enzyme and often participate in substrate binding

Question 4

What are metal ions of metalloenzymes

Answer 4

They are cations that are tigthly bound to enzyme and participate directly in catalysis (Fe, Zn, Cu, Co)

Question 5

What are coenzymes

Answer 5

Coenzymes are derivatives of vitamins without wich the enzyme cannot exhibit any reaction.
Coenzymes accepts a particular group removed from the substrate or donates a particular group to the substrate. It mainly transports groups btw enzyme

Question 6

What is a cosubstrates

Answer 6

They are coenzymes which are losely attached to the apoenzyme and are separated easily by dialysis

Question 7

What is thiamine pyrophosphate TPP

Answer 7

TPP is formed from thiamine in small intestine brain and liver
TPP coenzyme is required by enzymes in the decarboxylation of aloha keto acid