Cocaine and Amphetamine Flashcards
Cocaine Formulation- Powder
Cocaine hydrochloric salt White flakes, or powdery form Relatively stable, transports well Dissolves easily in water Intranasal and intravenous routes Most common form Often "cut" with many chemicals until final product is 12% cocaine
Alduterants to Cocaine
Mannitol- Mild baby laxative, low toxicity
Inositol- B vitamin, harmless but irritates nasal passages
Lidocaine- “active” adulterant is also a local anesthetic so difficult to detect; no euphoria but is self administered
PPA- phenylpropanolamine, an OTC nasal decongestant, high toxicity at high doses
Lactose- harmless, cheap and easy to get
Cocaine Formulation- other
Freebase Pure alkaloid waxy paste becomes oil Not very stable, breaks down easily Dissolves in lipid or fat Must be smoked Special small pipes are used
Crack Formulation
Freebase, less dangerous to make
Smoked in special crack pipes
Marketed in single doses
Epidemic in 1980
Cocaine Mechanism of Action
Dopamine is released –> Cocaine blocks reuptake inhibitors –> Increased dopamine levels in the synapse - Positive reinforcement Blocks sodium ion channels in the cell
Medical Uses- Cocaine
Schedule II
Local anesthetic for ophthalmic surgery and testing due to direct blockade on nerve impulses
Very effective in nasal, laryngeal and esophagus mucus membranes
Causes vasoconstriction, reduces bleeding
Can cause positive urine screening 2 days later
CNS energizing use ended due to short duration of action, rapid tolerance, dependence and side effects
Cocaine Absorption
Rapidly absorbed through IV, smoking, intranasal, oral
Short plasma life of 40-60 minutes
Cocaine Metabolism
Plasma and liver esterases metabolizes cocaine
50% metabolized within an hour
Rapid rise and fall of cocaine plasma levels causes a crash, leaves user wanting more
Cocaine Effects on CNS
Euphoria- sense of well being, greater self-esteem, alertness, energy
Cocaine Physiological Effects
Increased heart rate and increased blood pressure
Cocaine Patterns of Use
Chippers- Occasional use
“Binge”- finish all cocaine available
Other behaviors reduce- sleep, eating, sexual
If supply is limited than human and animals use until death
Crash at the end of use
Speedball
Cocaine + heroine
Heroine takes the edge of cocaine high
Can result in death if dose is too high
Cocaethylene
Cocaine + Ethyl Alcohol
Major metabolite benzoylecgonine is transesterified by ethanol to produce this
More toxic than cocaine and may contribute to overdoses when cocaine is used with alcohol
Tolerance- Cocaine
Unclear whether there is tolerance or sensitization
Sensitization to locomotor, stereotypic behaviors and convulsions
Tolerance to constant use
Sensitization- interval in between uses
No tolerance to blood pressure effects
Withdrawal- Cocaine
Thought that dependence did not occur
Abstinence causes crash, intense craving to cocaine
Individual will sleep and eat, but depressed, thoughts consumed by cocaine
More rapid of a crash= more frequent use