Coat Color_AG

Question 1

5 genes responsible for coat color

Answer 1

a: nonagouti locus
Tyr: albino locus
Tyrp1: brown locus
Myo5a: dilute locus
Oca2: pink eyed dilution locus

Question 2

genes named for one phenotype?

Answer 2

recessive

Question 3

Chr 4?

Answer 3

Tyrp1, tyrosinase related protein 1

Question 4

Chr 7?

Answer 4

Tyr: tyrosinase
Oca2: occulocutaneous albinism type II

Question 5

Chr 9?

Answer 5

Myo5a: myosin Va protein

Question 6

Chr 2?

Answer 6

a: binds aMSH receptor

Question 7

aa

Answer 7

black, unrestricted activation of aMSH resulting in fur that is entirely black

Question 8

two types of melanin?

Answer 8

pheomelanin: yellow/ red
eumelanin: black/ brown

Question 9

Tyr^c

Answer 9

albino, inactive form of tyrosinase produced so no melanin produced

Question 10

Tyrp^b

Answer 10

brown, last step of eumelanin production assisted by tyrosinase related protein 1, melanin granules more rounded in shape and appear brown (less eumelanin)

Question 11

Myo5a^d

Answer 11

overall dilute mouse color as myosin Va protein defects lead to redued melanosome trafficking and uneven release of melanin

Question 12

Oca2^p

Answer 12

pink eyed diluted coat color, may alter pH of melanosome leading to pink eyes and dilute coat color

Question 13

a, nonagouti gene dominance

Answer 13

A^y > A^w > A > a^t > a > a^e

Question 14

aa phenotype

Answer 14

nonagouti

Question 15

A or + phenotype

Answer 15

agouti

Question 16

a^e phenotype

Answer 16

extreme non agouti, black

Question 17

a^t phenotype

Answer 17

black and tan

Question 18

A^w phenotype

Answer 18

white bellied agouti

Question 19

A^y phenotype

Answer 19

yellow

Question 20

Tyr or Tyr^+ phenotype

Answer 20

pigmented

Question 21

Tyr^c phenotype

Answer 21

albino

Question 22

Tyr^c-ch phenotype

Answer 22

chinchilla

Question 23

Tyr^C-e phenotype

Answer 23

extreme dilution

Question 24

Tyr dominance

Answer 24

Tyr^+ > Tyr^c, Tyr^c-ch, Try C-e

Question 25

Myo5a^d phenotype

Answer 25

dilute

Question 26

Myo5a or Myo5a^+ phenotype

Answer 26

non dilute (wild type)

Question 27

Mlph^ln

Answer 27

leaden

Question 28

Ednrb^s

Answer 28

piebald, megacolon

Question 29

Oca2 or Oca2^+ phenotype

Answer 29

wildtype (normal eyes)

Question 30

Oca2^p phenotype

Answer 30

pink eyed dilution

Question 31

Tyrp1 or Tyrp1^+ phenotype

Answer 31

black (wild type)

Question 32

Tyrp1^B-lt phenotype

Answer 32

light

Question 33

Tyrp1^b phenotype

Answer 33

brown

Question 34

Tyrosinase related protein 1 dominance

Answer 34

Tyrp1+ > Tyrp1^b

Question 35

Tyrp1^b phenotype only visible if:

Answer 35

a/a (nonagouti) and Tyr^+ (non albino)`

Question 36

if albino (Tyr^c/ Tyr^c)…….can you see effects of Tyrp1 or a genes?

Answer 36

No!

Question 37

Tyr > a > Tyrp1

Answer 37

dominance

Question 38

ovarian transplant: host is A^w, ovarian tissue is B6. if pups are from host ovary, what color at “a” locus?

Answer 38

white bellied agouti (dominant to other alleles at “a” locus)

Question 39

Lyst^bg-J

Answer 39

beige mice, Chediak higashi model, Natural Killer cell deficiency

Question 40

Mlph^ln

Answer 40

leaden, looks like Myo5a^d (dilute, recessive phenotype)