Coagulation Time

Question 1

tests the composite action of all plasma factors acting simultaneously

Answer 1

coagulation time/clotting time

Question 2

time required for the blood to clot

Answer 2

coagulation time/clotting time

Question 3

a measure of the ability of the blood to clot and is NOT influenced by the platelet functions beside PF3 (tissue factor)

Answer 3

coagulation time

Question 4

measures only the required for the formation of the first traces of thrombin sufficient to produce a visible clot

Answer 4

coagulation time

Question 5

in coagulation time, what are we looking for?

Answer 5

traces or appearance of thrombin | visible clot

Question 6

what are the 2 capillary blood methods for coagulation time

Answer 6

slide/drop method and capillary tube method (dale and laidlaw’s method)

Question 7

a venous blood method of coagulation time

Answer 7

lee and white method (whole blood clotting time)

Question 8

in slide method, how many minutes is required to pass before drawing a fine wire or pin in the drop of blood?

Answer 8

3 minutes

Question 9

in slide method, drawing fine wire or pin in the drop of blood after 3 mins is repeated at what time interval?

Answer 9

30 second intervals

Question 10

what indicates the endpoint of slide method?

Answer 10

tiny strands of fibrin clinging to the wire or pin

Question 11

what is the reference range of slide/drop method of coagulation time?

Answer 11

2-4 minutes

Question 12

capillary tube method of blood coagulation is also known as?

Answer 12

dale and laidlaw’s method

Question 13

in capillary tube method, for how much blood is let to fill the tube?

Answer 13

2/3 of capillary tube length

Question 14

place the tube filled by capillary action for about ____ of its length

Answer 14

2/3

Question 15

in capillary tube method, how many minutes is required to pass before breaking off of blood filled capillary tube?

Answer 15

2 minutes

Question 16

at what length do we break the capillary tube filled with blood in capillary tube method?

Answer 16

1cm

Question 17

in capillary tube method, breaking off 1cm of the blood filled end of capillary tube after 2 minutes is done at what time interval?

Answer 17

30 second intervals

Question 18

what is the endpoint of capillary tube method?

Answer 18

presence of strands of fibrin with a gap of at least 5mm between the broken ends

Question 19

what should be the length of fibrin strands formed in capillary tube method

Answer 19

5mm

Question 20

what is the rreference range of capillary tube method

Answer 20

2-6 minutes

Question 21

a coagulation time method that is NOT standardized

Answer 21

capillary tube method (dale and laidlaw’s method)

Question 22

in capillary tube method, the color of the capillary tube is blue

Answer 22

false (color is not stated)

Question 23

lee and white method of coagulation time is also known as?

Answer 23

whole blood clotting time

Question 24

this method measures ALL INTRINSIC COAGULATION FACTORS (factor VI, VIII, IX, XI, XII, prekallikrein and HMWK)

Answer 24

lee and white method

Question 25

how many test tubes are required in lee and white method

Answer 25

3 test tubes

Question 26

how many cc of blood is withdrawn from the patient in lee and white method

Answer 26

4cc

Question 27

in lee and white method, we record the time of the first appearance of blood in the syringe

Answer 27

true

Question 28

in lee and white method, how many mL of blood is placed in each of the tubes in order of their number?

Answer 28

1mL

Question 29

in lee and white method, how many minutes is let to pass before tilting the 1st and 2nd tube?

Answer 29

3 minutes

Question 30

lee and white method: in testing the 3rd tube, we record the time when tube 3 can be inverted without disturbing the clot

Answer 30

true

Question 31

time elapsed from the first appearance of blood in the syringe and clot formation in the third tube is the coagulation time

Answer 31

true of lee and white method

Question 32

what is the reference range of lee and white method?

Answer 32

5-10 minutes

Question 33

why do we rinse the syringe and tubes with NSS?

Answer 33

to eliminate substances from syringe barrel and tube that may prematurely activate contact factors

Question 34

enumerate the 5 sources of error in lee and white method

Answer 34

(1) faulty technique (2) inappropriate blood volume (3) air bubbles in syringe (4) cleanliness of glasswares and syringe (5) constant agitation

Question 35

coagulation method that do not have tissue fluid contamination making it as its advantage

Answer 35

lee and white method

Question 36

this coagulation method can use control if there is a known sample

Answer 36

lee and white method

Question 37

disadvantage of lee and white method

Answer 37

it requires venipuncture (if syringe or tubes are contaminated, results are affected)

Question 38

prolonged coagulation time is observed in what condition?

Answer 38

hemophilia (A and/or B)

Question 39

hemophilia a is caused by what blood coagulation factor

Answer 39

lack of factor VIII

Question 40

hemophilia b is caused by what blood coagulation factor

Answer 40

lack of factor IX

Question 41

aside from hemophilia, enumerate diseases where prolonged coagulation is occasionally seen

Answer 41

(1) obstructive jaundice (2) anemia (3) leukemia (4) hemorrhagic disease of the newborn (HDN) (5) acute fever

Question 42

vitamin k malabsorption coagulation time?

Answer 42

prolonged