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Hematology 2 > Coagulation Time > Flashcards

Coagulation Time Flashcards

1
Q

tests the composite action of all plasma factors acting simultaneously

A

coagulation time/clotting time

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2
Q

time required for the blood to clot

A

coagulation time/clotting time

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3
Q

a measure of the ability of the blood to clot and is NOT influenced by the platelet functions beside PF3 (tissue factor)

A

coagulation time

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4
Q

measures only the required for the formation of the first traces of thrombin sufficient to produce a visible clot

A

coagulation time

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5
Q

in coagulation time, what are we looking for?

A

traces or appearance of thrombin | visible clot

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6
Q

what are the 2 capillary blood methods for coagulation time

A

slide/drop method and capillary tube method (dale and laidlaw’s method)

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7
Q

a venous blood method of coagulation time

A

lee and white method (whole blood clotting time)

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8
Q

in slide method, how many minutes is required to pass before drawing a fine wire or pin in the drop of blood?

A

3 minutes

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9
Q

in slide method, drawing fine wire or pin in the drop of blood after 3 mins is repeated at what time interval?

A

30 second intervals

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10
Q

what indicates the endpoint of slide method?

A

tiny strands of fibrin clinging to the wire or pin

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11
Q

what is the reference range of slide/drop method of coagulation time?

A

2-4 minutes

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12
Q

capillary tube method of blood coagulation is also known as?

A

dale and laidlaw’s method

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13
Q

in capillary tube method, for how much blood is let to fill the tube?

A

2/3 of capillary tube length

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14
Q

place the tube filled by capillary action for about ____ of its length

A

2/3

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15
Q

in capillary tube method, how many minutes is required to pass before breaking off of blood filled capillary tube?

A

2 minutes

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16
Q

at what length do we break the capillary tube filled with blood in capillary tube method?

A

1cm

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17
Q

in capillary tube method, breaking off 1cm of the blood filled end of capillary tube after 2 minutes is done at what time interval?

A

30 second intervals

18
Q

what is the endpoint of capillary tube method?

A

presence of strands of fibrin with a gap of at least 5mm between the broken ends

19
Q

what should be the length of fibrin strands formed in capillary tube method

A

5mm

20
Q

what is the rreference range of capillary tube method

A

2-6 minutes

21
Q

a coagulation time method that is NOT standardized

A

capillary tube method (dale and laidlaw’s method)

22
Q

in capillary tube method, the color of the capillary tube is blue

A

false (color is not stated)

23
Q

lee and white method of coagulation time is also known as?

A

whole blood clotting time

24
Q

this method measures ALL INTRINSIC COAGULATION FACTORS (factor VI, VIII, IX, XI, XII, prekallikrein and HMWK)

A

lee and white method

25
Q

how many test tubes are required in lee and white method

A

3 test tubes

26
Q

how many cc of blood is withdrawn from the patient in lee and white method

A

4cc

27
Q

in lee and white method, we record the time of the first appearance of blood in the syringe

A

true

28
Q

in lee and white method, how many mL of blood is placed in each of the tubes in order of their number?

A

1mL

29
Q

in lee and white method, how many minutes is let to pass before tilting the 1st and 2nd tube?

A

3 minutes

30
Q

lee and white method: in testing the 3rd tube, we record the time when tube 3 can be inverted without disturbing the clot

A

true

31
Q

time elapsed from the first appearance of blood in the syringe and clot formation in the third tube is the coagulation time

A

true of lee and white method

32
Q

what is the reference range of lee and white method?

A

5-10 minutes

33
Q

why do we rinse the syringe and tubes with NSS?

A

to eliminate substances from syringe barrel and tube that may prematurely activate contact factors

34
Q

enumerate the 5 sources of error in lee and white method

A

(1) faulty technique
(2) inappropriate blood volume
(3) air bubbles in syringe
(4) cleanliness of glasswares and syringe
(5) constant agitation

35
Q

coagulation method that do not have tissue fluid contamination making it as its advantage

A

lee and white method

36
Q

this coagulation method can use control if there is a known sample

A

lee and white method

37
Q

disadvantage of lee and white method

A

it requires venipuncture (if syringe or tubes are contaminated, results are affected)

38
Q

prolonged coagulation time is observed in what condition?

A

hemophilia (A and/or B)

39
Q

hemophilia a is caused by what blood coagulation factor

A

lack of factor VIII

40
Q

hemophilia b is caused by what blood coagulation factor

A

lack of factor IX

41
Q

aside from hemophilia, enumerate diseases where prolonged coagulation is occasionally seen

A

(1) obstructive jaundice
(2) anemia
(3) leukemia
(4) hemorrhagic disease of the newborn (HDN)
(5) acute fever

42
Q

vitamin k malabsorption coagulation time?

A

prolonged

Hematology 2 (2 decks)

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