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Coagulation General Information Flashcards

1
Q

Factor I Name

A

Fibrinogen

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2
Q

Factor I Inherited Frequency

A

Rare

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3
Q

Factor I Conversion

A

Fibrin by thrombin

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4
Q

Factor II Name

A

Prothrombin

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5
Q

Factor II Inherited Frequency

A

Rare

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6
Q

Factor II Comment

A

Precursor to thrombin

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7
Q

Factor III Name

A

Tissue Factor (TF)

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8
Q

Factor III Comment

A

Phospholipid released from injured vessel wall
Not normally found in blood

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9
Q

Factor IV Name

A

Calcium

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10
Q

Factor IV Comment

A

Bound by anticoagulant sodium citrate
Using citrated plasma, must be supplied by reagent

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11
Q

Factor V Name

A

Labile factor
Proaccelerin

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12
Q

Factor V Inherited

A

Rare

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13
Q

Factor V Comment

A

Deteriorates rapidly

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14
Q

Factor VII Name

A

Stable factor
Preconvertin

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15
Q

Factor VII Inherited

A

Rare

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16
Q

Factor VIII Name

A

Antihemophilic factor

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17
Q

Factor VIII Inherited

A

Common
Hemophilia A

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18
Q

Factor VIII Comment

A

Circulates in association with VWF

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19
Q

Factor VIII:C

A

Coagulation portion
Extremely labile

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20
Q

Factor IX Name

A

Christmas factor
Plasma thromboplastin component

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21
Q

Factor IX Inherited

A

Common
Hemophilia B

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22
Q

Factor X Name

A

Stuart factor

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23
Q

Factor X Inherited

24
Q

Factor XI Name

A

Plasma thromboplastin antecedent

25
Factor XI Inherited
Rare Hemophilia C May or may not cause bleeding
26
Factor XII Name
Hageman factor Contact Factor
27
Factor XII Inherited
No bleeding
28
Factor XII Comment
Glass activation factor Not part of invivo coagulation
29
Factor XIII Name
Fibrin stabilizing factor
30
Factor XIII Inherited
Rare Poor Wound healing
31
Factor XIII Comment
Stabilizes fibrin clot
32
Factor HMWK Name
High Molecular Weight Kininogen Fitzgerald Factor
33
Factor HMWK Inherited
Rare No Bleeding
34
Factor HMWK Comment
Not part of in vivo coagulation
35
Factor PK Name
Prekallikrein Fletcher Factor
36
Factor PK Inherited
No Bleeding
37
Factor PK Comment
Not part of in vivo coagulation
38
Substrate
Substance changed by an enzyme Fibrinogen
39
Cofactor
Protein that accelerates enzymatic reactions No enzymatic activity of its own V (cofactor for Xa) VIII (cofactor for IXa)
40
Enzyme
Protein that catalyzes a change in specific substrate Secreted in inactive form (proenzyme, zymogen) Must be activated to function
41
Examples of Enzyme
Serine proteases Thrombin (IIa) VIIa IXa Xa XIa XIIa Prekallikrein Transglutaminase: XIIIa
42
Contact group
Factors involved in initiation of intrinsic pathway PK, HMWK, XII, XI
43
Prothrombin Group
Vitamin K dependent factors II, VII, IX, X
44
Fibrinogen group
Factors acted on by thrombin High molecular weight proteins I, V, VIII, XIII V, VIII, XIII - activated I - converted to fibrin
45
Factors in extrinsic pathway
TF, VII
46
Factors in intrinsic pathway
PK, HMWK, XII, XI, IX, VIII
47
Factors in common pathway
X, V, II, I
48
Extrinsic tenase complex
VIIa, TF Acts on X
49
Intrinsic tenase complex
IXa, VIIIa Acts on X
50
Prothrombinase complex
Xa, Va Acts on prothrombin
51
Factor VIII complex
VIII:C & Von Willebrand factor (VWF) VIII:C is the procoagulant VWF is the carrier protein
52
All produced in which organ?
Liver
53
Factors Needed Vitamin K
II, VII, IX, X
54
Affected by anticoagulant therapy
Coumadin, Warfarin II, VII, IX, X
55
Factors consumed during clotting
I, II, V, VIII, XIII Not present in serum
56
Labile Factors
V, VIII

Coagulation (6 decks)

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