Coagulation General Information Flashcards
Factor I Name
Fibrinogen
Factor I Inherited Frequency
Rare
Factor I Conversion
Fibrin by thrombin
Factor II Name
Prothrombin
Factor II Inherited Frequency
Rare
Factor II Comment
Precursor to thrombin
Factor III Name
Tissue Factor (TF)
Factor III Comment
Phospholipid released from injured vessel wall
Not normally found in blood
Factor IV Name
Calcium
Factor IV Comment
Bound by anticoagulant sodium citrate
Using citrated plasma, must be supplied by reagent
Factor V Name
Labile factor
Proaccelerin
Factor V Inherited
Rare
Factor V Comment
Deteriorates rapidly
Factor VII Name
Stable factor
Preconvertin
Factor VII Inherited
Rare
Factor VIII Name
Antihemophilic factor
Factor VIII Inherited
Common
Hemophilia A
Factor VIII Comment
Circulates in association with VWF
Factor VIII:C
Coagulation portion
Extremely labile
Factor IX Name
Christmas factor
Plasma thromboplastin component
Factor IX Inherited
Common
Hemophilia B
Factor X Name
Stuart factor
Factor X Inherited
Rare
Factor XI Name
Plasma thromboplastin antecedent
Factor XI Inherited
Rare
Hemophilia C
May or may not cause bleeding
Factor XII Name
Hageman factor
Contact Factor
Factor XII Inherited
No bleeding
Factor XII Comment
Glass activation factor
Not part of invivo coagulation
Factor XIII Name
Fibrin stabilizing factor
Factor XIII Inherited
Rare
Poor Wound healing
Factor XIII Comment
Stabilizes fibrin clot
Factor HMWK Name
High Molecular Weight Kininogen
Fitzgerald Factor
Factor HMWK Inherited
Rare
No Bleeding
Factor HMWK Comment
Not part of in vivo coagulation
Factor PK Name
Prekallikrein
Fletcher Factor
Factor PK Inherited
No Bleeding
Factor PK Comment
Not part of in vivo coagulation
Substrate
Substance changed by an enzyme
Fibrinogen
Cofactor
Protein that accelerates enzymatic reactions
No enzymatic activity of its own
V (cofactor for Xa)
VIII (cofactor for IXa)
Enzyme
Protein that catalyzes a change in specific substrate
Secreted in inactive form (proenzyme, zymogen)
Must be activated to function
Examples of Enzyme
Serine proteases
Thrombin (IIa)
VIIa
IXa
Xa
XIa
XIIa
Prekallikrein
Transglutaminase: XIIIa
Contact group
Factors involved in initiation of intrinsic pathway
PK, HMWK, XII, XI
Prothrombin Group
Vitamin K dependent factors
II, VII, IX, X
Fibrinogen group
Factors acted on by thrombin
High molecular weight proteins
I, V, VIII, XIII
V, VIII, XIII - activated
I - converted to fibrin
Factors in extrinsic pathway
TF, VII
Factors in intrinsic pathway
PK, HMWK, XII, XI, IX, VIII
Factors in common pathway
X, V, II, I
Extrinsic tenase complex
VIIa, TF
Acts on X
Intrinsic tenase complex
IXa, VIIIa
Acts on X
Prothrombinase complex
Xa, Va
Acts on prothrombin
Factor VIII complex
VIII:C & Von Willebrand factor (VWF)
VIII:C is the procoagulant
VWF is the carrier protein
All produced in which organ?
Liver
Factors Needed Vitamin K
II, VII, IX, X
Affected by anticoagulant therapy
Coumadin, Warfarin
II, VII, IX, X
Factors consumed during clotting
I, II, V, VIII, XIII
Not present in serum
Labile Factors
V, VIII
