Coagulation Exercises

Question 1

A patient with menorrhagia, gum bleeding, and easy bruising likely has dysfunction of what aspect of the coagulation cascade?

Answer 1

platelet dysfunction

Question 2

What will type 1 von willebrand disease look like on labs?

Answer 2

low Factor 8
low vWF antigen
low ristocetin cofactor activity

normal distribution of vWF factor multimer analysis

Question 3

What will type 2a vWF def look like on labs?

Answer 3

low Factor 8
low vWF antigen
low Ristoceint cofactor activity
decreased high molecular weight multimers on the von willebrand factor multimer analysis

Question 4

What will type 2n vWF def look like on labs?

Answer 4

severely low factor 8
normal vWF antigen
Normal ristocetin cofactor
normal multiple analysis

Question 5

What will type 3 vWF def look like on labs?

Answer 5

very low factor 8
very low vWF antigen
very low ristocein cofactor activity

so very low in all 3!

Question 6

What do the PFA-100Col/Epi and PFA-100 Col/ADP tests look at in general terms?

Answer 6

palatelet function

if they are prolonged, there’s something wrong with how the platelets reacct to epi and ADP

Question 7

What medication will increase the Col/Epi test, but not the Col/ADP test?

Answer 7

aspirin

Question 8

Will thrombocytopenia increase the PFA EPI and PFA ADP test?

Answer 8

yes