Coagulation Cascade Flashcards
1
Q
Where are the clotting factors made?
A
Liver
2
Q
What are the 2 routes for activation of clotting factors?
A
Intrinsic and Extrinsic pathway
3
Q
What causes activation of the intrinsic pathway?
A
contact with collagen from damaged blood vessels
4
Q
What causes activation of the extrinsic pathway?
A
contact with a tissue factor from the surface of extravascular cells
5
Q
What are the natural inhibitors of the fibrin clot?
A
- Protein C
- Protein S
- Antithrombin III
6
Q
What dissolves the fibrin clot?
A
Plasminogen
7
Q
What increases plasmin activity?
A
Recombinant plasminogen activator (rTPA)
