Coagulation Cascade Flashcards
1
Q
How is the Intrinsic pathway initiated?
A
It is activated by the negative charged surface such as glass beads
2
Q
How is the extrinsic pathway initiated?
A
It is activated by the binding of tissue factor to factor VII
3
Q
What is factor II?
A
Prothrombin
4
Q
What is factor IIa?
A
Thrombin
5
Q
What Factors depend on Calcium for assembly of reaction complexes?
A
Factors II, VII, IX, X
6
Q
Where does Calcium bind in Factors II, VII, IX and X?
A
They bind to Gamma-Carboxylated Glutamic Acid
7
Q
What cofactor converts Glutamate to Gamma-Carboxylated Glutamic Acid?
A
Vitamin K
8
Q
What Drug inhibits conversion of glutamate to gamma- carboxylated glutamic acid?
A
Coumadin
