Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hematology 2 > Coagulation and Fibrinolysis > Flashcards

Coagulation and Fibrinolysis Flashcards

1
Q

Factors that are most prominent bleeding disorders that occur in patients who survive gestation and birth.

A

Factors 8 and 9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Two critically important assemblies that are essential for normal hemostasis

A

tenase and prothrombinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Major inhibitor of tPA and TcuPA

A

Plasminogen activator inhibitor-1 (PAI-1)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Most potent and highly selective inhibitor of plasmin.

A

α2-Antiplasmin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Three major anticoagulant systems regulate the enzymes of the coagulation protein system to help to inhibit clot formation.

A

protein C/protein S system, the plasma serine protease inhibitor system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Regulated by natural anticoagulants and the fibrinolytic system to avoid thrombus formation and extension

A

Coagulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Kunitz-type serine protease inhibitor

A

TFPI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Main serine protease inhibitor of coagulation enzymes of the plasma serine protease inhibitor system

A

Antithrombin (antithrombin III)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

When activated, protein C, _____________________, is an enzyme that functions as an inhibitor

A

a 62-kDa vitamin K–dependent protein,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Protein C is activated by thrombin when bound to an endothelial cell protein

A

Thrombomodulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

A 69-kDa vitamin K–dependent protein, is not an enzyme

A

Protein S

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

It is a cofactor, or receptor, for activated protein C on cell membranes.

A

Protein S

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Most potent inhibitor of FXIIa, kallikrein, and FXIa in plasma

A

C1 inhibitor
(C1 esterase inhibitor)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Regulate the amount of free bradykinin in the intravascular compartment and reduce inflammatory events

A

C1 inhibitor (C1 esterase inhibitor)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Causative factor for types I and II hereditary angioedema, a disorder associated with excessive bradykinin delivered to tissues.

A

C1 inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Most potent inhibitor of the FVIIa–tissue factor complex.

A

Tissue Factor Pathway Inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Only approximately ____% of TFPI circulates in plasma associated with lipoproteins

A

20%

18
Q

Cerebral anticoagulant

A

amyloid β-protein precursor (AβPP)

19
Q

Produce vasoactive hormones able to control the primary phase of hemostasis.

A

Endothelial cells

20
Q

Vasodilator, and it inhibits platelet aggregation

A

Prostacyclins (PGI2)

21
Q

Also known as cartilage oligomeric matrix protein (COMP)

A

Thrombospondin-5

22
Q

An extracellular protein able to control vascular tone

A

Thrombospondin-5

23
Q

Inhibits thrombin and acts as a natural anticoagulant in mice

A

COMP

24
Q

Determines a dose-dependent prolongation of thrombin time.

A

COMP

25
Q

TF is not fully active on intact cells; it becomes able to activate coagulation when cell membrane properties are modified.

A

Decryption” of “encrypted

26
Q

Two assays most commonly used to examine the coagulation system

A

APTT and PT

27
Q

Induced by surface (contact) activation of the system

A

APTT

28
Q

Induced by the addition of excess tissue factor

A

PT

29
Q

They are also referree to as “point of care” tests

A

APTT and PT

30
Q

Example of screening assay for primary hemostasis

A

Platelet count

31
Q

The recommended anticoagulant for APTT

A

3.2 g% sodium citrate

32
Q

Reversible chelator of calcium that prevents coagulation protein activation.

A

Sodium citrate

33
Q

Ratio of anticoagulant to whole blood

A

1 part anticoagulant to 9 parts whole blood

34
Q

APTT assesses the coagulation proteins: 2 pathways

A

intrinsic system and common pathways

35
Q

Serves as the basis for the international normalized ratio (INR) value used to monitor anticoagulation with warfarin or other vitamin-antagonists

A

PT

36
Q

Direct measure of fibrinogen function and may be used to ascertain if there is a defect in fibrinogen function

A

thrombin clotting time

37
Q

Abnormal protein fibrinogen

A

dysfibrinogenemia

38
Q

Measures the overall tendency of a plasma sample to form thrombin after initiation of coagulation

A

Thrombin Generation assay

39
Q

Plasma-based spectrophotometric global assay

A

Overall Hemostasis Potential

40
Q

Ancillary parameters of OHP

A

Overall coagulation potential and overall fibrinolytic potential

Hematology 2 (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions