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med phys 2/3 > Coagulation > Flashcards

Coagulation Flashcards

1
Q

Five components of the hemostasis system

A

Vascular
Platelet

Coagulation

Anti-coagulation

Fibrinolysis

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2
Q

Platelet glycoproteins

A

GPI-beta-alpha
GPVI

GPIIa/IIIb

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3
Q

Platelet G protein-coupled receptors

A

P2Y12
Protease activated receptor

Thromboxane A2 receptor

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4
Q

GPI-beta-alpha ligand

A

von Willebrand factor (vWf)

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5
Q

GPVI ligand

A

Collagen

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6
Q

GPIIa/IIIb ligand

A

Fibrinogen

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7
Q

P2Y12 ligand

A

ADP

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8
Q

Protease activated receptor (PAR) ligand

A

Thrombin

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9
Q

Thromboxane A2 receptor ligand

A

Thromboxane A2

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10
Q

Factor I name and function

A

“Fibrinogen”

Converted into fibrin (by thrombin), which forms the fibrin blood clot

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11
Q

Factor II name and function

A

“Prothrombin”
Is converted into thrombin, which cleaves fibrinogen

Activates Factor XIII into Factor XIIIa (crosslinks fibrin fibers)

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12
Q

Factor III name and function

A

“Tissue factor”
Exposed to Factor VII when vascular injury occurs, and activates this into Factor VIIa

Factor III/Factor VIIa/Ca2+ activates Factor X into Factor Xa

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13
Q

Factor IV name and function

A

“Ca2+”

Cofactor with most coagulation factors

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14
Q

Factor V function

A

Released by activated platelets

Converted into Factor Va by thrombin

Forms complex with Factor Xa, Ca2+, and phospholipids to form the prothrombin activator complex, which converts prothrombin into thrombin

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15
Q

Factor VI function

A

There is NO Factor VI

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16
Q

Factor VII function

A

Activated by tissue factor (into Factor VIIa)

Factor VIIa/tissue factor/Ca2+ activates Factor X into Factor Xa

17
Q

Factor VIII function

A

Activated by thrombin (into Factor VIIIa)
Factor VIIIa/Factor IXa/Ca2+/phospholipids (tenase complex)

Tenase complex activates Factor X

18
Q

Factor IX function

A

Activated by Factor XIa (into Factor IXa)

Part of the tenase complex (Factor VIIIa/Factor IXa/Ca2+/PL) that activates Factor X

19
Q

Factor X function

A

Activated by the tenase complex (Factor VIIIa/Factor IXa/Ca2+/PL) into Factor Xa
Forms the prothrombin complex with Factor Va, Ca2+, and PL, which converts prothrombin into thrombin

20
Q

Factor XI function

A

Activated by Factor VIIa into Factor XIa

Activates Factor IX

21
Q

Factor XII function

A

Activated when exposed to collagen (into Factor XIIa)

Activates Factor XI

22
Q

Factor XIII function

A

Activated by thrombin (into Factor XIIIa)

Crosslinks fibrin fibers to form secure fibrin clot

23
Q

Which clotting factors require vitamin K?

A

Factors II, VII, IX, and X

med phys 2/3 (10 decks)

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