Coagulants - Unit 2

Question 1

Name the four targets of anti-platelet drugs

Answer 1

1) TXA2 inhibition ; 2) ADP inhibition; 3) GPIIb/IIIa inhibition (aka integrin inhibitors or fibrinogen receptors); 4) phosphodiesterase inhibitors (which increase cAMP)

All prevent aggregation

Question 2

Name the four classes of anticoagulant drugs

Answer 2

1) indirect thrombin inhibitors (heparin); 2) vit K antagonists (warfarin); 3) direct thrombin inhibitors; 4) direct Xa inhibitors

Question 3

Name the type of drug fibrinolytics are

Answer 3

plasminogen activators

Question 4

What drug prevents formation of TXA2?

Answer 4

aspirin

Question 5

Name 3 dugs that are ADP blockers

Answer 5

grels: clopidogrel, prasurgrel, ticargrelor

Question 6

Name the 3 drugs that are GPIIb/IIIa inhibitors

Answer 6

TEA: tirofiban, epitifibatide, abiciximab

Question 7

Name the 2 drugs that are PDE inhibitors

Answer 7

dipyridamole, cilastozol

Question 8

Name 4 indirect thrombin inhibitors (2 are lower weight)

Answer 8

heparin, enoxaparin, dalteparin (both prior are LMWH), and fondaparinux

Question 9

Name 3 direct thrombin inhibitors and when they are indicated

Answer 9

bivalrudin (PTCA/PCI), argatroban (for pts with HIT), dabigatran (non-valvular afib)

Question 10

Name 2 direct Xa inhibitors

Answer 10

rivaroXaban and apiXaban

Question 11

Name 3 fibrinolytic drugs and which one is the most clot specific

Answer 11

alteplase, reteplase, tenecteplase (most clot specific)

Question 12

Anti platelets are useful for ___ thromboses, and anti-coagulants are useful for ___ thromboses.

Answer 12

arterial; venous