Coag—P2Y12 platelet reactivity testing

Question 1

purpose of platelet reactivity testing

Answer 1

measure a patient’s platelet response to anti-platelet drugs (clopidogrel, prasugrel)

Question 2

platelet reactivity instrument

Answer 2

VerifyNow

Question 3

VerifyNow measures the… of the platelets

why?

Answer 3

reactivity of the P2Y12 receptor

anti-platelet drugs block this receptor

Question 4

example of usefulness of platelet reactivity testing

Answer 4

to decide if surgery is safe for a patient on anti-platelet therapy

Question 5

the P2Y12 test is based on the ability of…

Answer 5

activated platelets to bind fibrinogen

Question 6

platelet reactivity test reagent

Answer 6

ADP/PGE1

Question 7

during platelet reactivity testing, light transmittance ——- as activated platelets bind and aggregate fibrinogen-coated beads

Answer 7

increases

Question 8

units reported on VerifyNow

Answer 8

P2Y12 reaction units (PRU)

Question 9

3 elements of platelet reactivity response curve

Answer 9

1. speed of rxn (slope)
2. extent of reaction (maximum amplitude)
3. time course of reaction